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Spatial transcriptomics: Highlights of S3000 platform

Spatial transcriptomics is a technique that can highly benefit from the technical developments the modern days keep bringing on. In this aspect, the upgrade from S1000 to S3000 in this platform, brought a series of improvements that make it such an interesting option to study tissues:

   • Sub-cellular resolution: Leading to in higher gene and UMI detection per cells, the new chips developed have improved clustering and overall, finer detail that matches the tissue’s structure.

   • Multi-level resolution analysis: Flexible multi-level analysis ranging from 100 μm to 5 μm to resolve diverse tissue features at optimal resolution.

   • The use of “Three in one slide” cell segmentation technology: Combining fluorescence staining, H&E staining, and RNA sequencing on a single slide, our “three-in-one” analysis algorithm allow us to retain the spatial information within the tissue that is going to be sequenced, allowing a subsequent cell-based transcriptomics.

   • Compatible with multiple sequencing platforms: Both options NGS and long-read sequencing available, so the information obtained can be processed in an appropriate way to fulfil the experiment’s objectives.

   • Flexible design of 1-8 active capture area: The size of the capture area is flexible, being possible to use 3 formats to ensure the optimal design fit.

   • Comprehensive bioinformatics and user-friendly visualization of results:  Our package includes 29 analyses and 100+ high-quality figures, combined with the use of inhouse developed software to visualize and customize cell splitting and spot clustering.

Spatial transcriptomics is a technique that will be further developed in the future, there is no doubt, but in this version, it is already creating an interesting data set with a high degree of diversity within the application of the results.