Featured Capture Efficiency Solutions
High-Performance Next-Generation Sequencing & Targeted Assay Kits for Regional Researchers
The Growing Need for High Capture Efficiency in Bangkok's Bio-Economy
How Cutting-Edge Multi-Omics and High-Throughput Sequencing Are Transforming Thailand's Scientific Ecosystem
Bangkok has emerged as the vibrant heart of biotechnology innovation, clinical diagnostic advancement, and agricultural life sciences across the ASEAN region. Supported by Thailand’s Bio-Circular-Green (BCG) Economy Model and initiative-driven infrastructure such as Thailand Science Park and the Eastern Economic Corridor (EEC), local academic institutions, medical hubs, and agricultural enterprises are rapidly modernizing their genomic workflows.
In next-generation sequencing (NGS) and multi-omics workflows, Capture Efficiency is the central determinant of data quality, turnaround speed, and project cost-effectiveness. High capture efficiency minimizes off-target sequencing noise, maximizes target enrichment ratio for degraded or complex samples, and ensures deep coverage over critical regions—such as promoter CpG islands, rare transcripts, or targeted genomic markers.
Whether analyzing recalcitrant plant tissues (such as sugarcane, rubber, and cassava), characterising marine microbiome samples from aquaculture farms along the Gulf of Thailand, or running targeted epigenetic biomarker profiling for clinical research in Bangkok's top university hospitals, achieving maximum capture efficiency ensures reproducible results and actionable biological insights.
Key Advantages of Maximum Capture Efficiency
- Reduced Sequencing Waste: Focuses sequencing depth strictly on targeted genomic regions, saving sequencing bandwidth.
- High Sensitivity for Low-Input Samples: Enables deep profiling from precious biological specimens, micro-dissected tissues, or environmental swab samples.
- Robust Bioinformatic Concordance: Accelerates downstream analysis on cloud platforms like BMKCloud by providing high signal-to-noise ratio data.
- Economical Scale-up: Significantly lowers per-sample cost for large breeding panels, population epigenetics, and cohort studies.
Key Genomics & Bio-Technology Trends in Bangkok
Precision Tropical Agriculture
Thailand is a global exporter of rice, cassava, tropical fruits, and natural rubber. Local researchers in Bangkok utilize targeted sequence capture, Bulked Segregant Analysis (BSA), and whole-genome resequencing to rapidly identify disease-resistance loci and heat-tolerant QTLs.
Aquaculture Metagenomics
Shrimp and tilapia aquaculture operations require rigorous water and gut microbiome monitoring. Amplicon profiling (16S/18S/ITS) combined with automated library preparation guarantees high capture of pathogenic microbes before disease outbreaks occur.
Epigenetics & Translational Medicine
Bangkok's biomedical institutions lead Southeast Asia in chronic disease research. High-efficiency methylome capture like RRBS and circular RNA (circRNA) sequencing are opening new frontiers in non-invasive biomarker discovery and oncology profiling.
About Biomarker Technologies (BMKGene)
16+ Years of Continuous Innovation in High-Throughput Sequencing & Bioinformatics
Global Genomics Expertise
Biomarker Technologies (BMKGene), founded in 2009, is a leading global genomics service provider with over 16 years of continuous innovation in high-throughput sequencing and bioinformatics. Backed by more than 60 national invention patents and 200+ software copyrights, we deliver comprehensive multi-omics solutions—spanning genomics, metagenomics, epigenetics, single-cell omics, transcriptomics, and our proprietary BMKMANU S3000 spatial transcriptome technology—supported by our advanced BMKCloud bioinformatics platform.
We have established long-term collaborations with research organizations across 84 regions worldwide, providing reliable genomic solutions on a global scale. Our regional presence ensures that researchers in Bangkok and across Southeast Asia receive seamless sample logistics, technical consultation, and rapid data delivery.
State-of-the-Art Laboratory Infrastructure
Operating over 20,000 square feet of advanced biomolecular laboratories, BMKGene maintains standardized rooms for sample extraction, library construction, ultra-clean processing, and high-throughput sequencing under strict SOPs.
By combining multi-platform sequencing technologies with automated liquid handling systems, we consistently deliver high capture efficiency, minimal batch-to-batch variation, and rapid turnaround times tailored to demanding research deadlines.
Leading Multi-level Platforms
PacBio platforms: Sequel II, Sequel, RSII
Nanopore platforms: PromethION P48, GridION X5 MinION
10X Genomics: 10X ChromiumX, 10X Chromium Controller
Illumina platforms: NovaSeq
BGI platforms: DNBSEQ-G400, DNBSEQ-T7
Bionano Irys system
Mass Spectrometry: Waters XEVO G2-XS QTOF, QTRAP 6500+
Professional Automatic Laboratory
Over 20,000 square feet facility equipped with advanced biomolecular laboratory instruments. Standardized workflows from sample extraction to sequencing operate under strict SOPs to ensure reliable, high-efficiency data output.
Self-Developed BMKCloud Platform
Self-developed BMKCloud bioinformatics platform powered by CPUs with 41,104 memory and 3 PB total storage. Features 4,260 computing cores with a peak computing power exceeding 121,708.8 Gflop per second for seamless multi-omics integration.
Automated High-Throughput Production Line
Brilliant Lab 1000 (BL1000): Maximizing NGS Library Construction Efficiency
Fully Automated Platform for Next-Generation Sequencing -- Brilliant Lab 1000
Biomarker Technologies (BMKGENE) and PerkinElmer have jointly built a fully automated experimental production line, named Brilliant Lab 1000 (BL1000), specifically engineered for high-throughput NGS library construction services.
By eliminating manual pipetting inconsistencies and optimizing reaction kinetics, BL1000 vastly enhances target capture efficiency, library consistency, and operational throughput. BMKGENE continuously strives to expand and refine our full sequencing product line in terms of diversity, production capacity, delivery precision, and cycle speed—delivering uncompromised quality to our partners in Bangkok and globally.
Key Benefit for Bangkok Projects: Accelerated delivery timelines for large-scale agricultural and clinical cohort projects with batch consistency guaranteed by robotics.
State-of-the-Art Factory Infrastructure
Localized Application Scenarios in Thailand
Empowering Agricultural Breeding, Environmental Conservation, and Biomedical Research
| Application Domain | Technological Solution | Impact on Bangkok & Regional Research |
|---|---|---|
| Crop Genetic Breeding | BSA (Bulked Segregant Analysis) & Plant/Animal WGS | Accelerates marker-assisted selection (MAS) for economic crops (rice, cassava, durian) by identifying causative QTLs for drought, salinity, and pest resistance. |
| Epigenetic Crop Resilience | Reduced Representation Bisulfite Sequencing (RRBS) | Maps DNA methylation dynamics under heat stress in tropical plants, revealing epigenetic mechanisms for climate adaptation without genomic mutation. |
| Aquaculture & Soil Health | Amplicon Metagenomics (16S/18S/ITS) | Monitors gut microbiota in black tiger shrimp and soil microbiome health across Central Thailand river basins, ensuring sustainable bio-farming. |
| Non-Coding RNA Biomarkers | circ-RNA & CircRNA Sequencing (Illumina) | Provides precise structural characterization of circular RNAs for biomarker discovery in viral vector studies, oncology, and metabolic disorders. |
| Novel Organism Discovery | Non-Reference based mRNA Sequencing & Proteomics | Enables comprehensive transcriptomic and proteomic profiling for endemic Southeast Asian flora and fauna without existing reference genomes. |
In-Depth Application Case Studies in Bangkok
Case Study 1: Heat & Drought Adaptation in Cassava and Rice
Agricultural institutes in Greater Bangkok frequently encounter challenges with environmental stress in staple crops. Utilizing BMKGene's Bulked Segregant Analysis (BSA) combined with high-coverage Whole Genome Sequencing, local plant geneticists compare extreme phenotyped pools (e.g., highly resistant vs. susceptible plants). By leveraging our automated capture library preparation, researchers map targeted resistance regions within weeks rather than years, vastly cutting down field trial cycles.
Case Study 2: Marine Aquaculture & Pathogen Surveillance
Shrimp farming along the coastal provinces surrounding Bangkok relies on early detection of bacterial and fungal pathogens. Using BMKGene's Amplicon (16S/18S/ITS) sequencing platform, environmental water samples and intestinal tracts of shrimp are systematically analyzed. High capture efficiency ensures even low-abundance pathogens are detected early, providing actionable predictive bio-security intelligence to farm managers.
Case Study 3: Epigenomic Profiling via RRBS for Tropical Medicine
At medical research institutes in Bangkok, understanding epigenetic modifications in response to tropical viral infections and chronic lifestyle diseases is a high priority. Reduced Representation Bisulfite Sequencing (RRBS) enriches CpG-rich genomic regions using restriction digestion, providing high single-nucleotide methylation resolution at a fraction of the cost of full bisulfite sequencing. This enables high-throughput clinical sample screening with high reproducibility.
Enterprise Qualification & Intellectual Property
Certified Excellence Supported by Global Standards and Joint Academic Laboratories
Comprehensive BMKGene Product Portfolio
Explore Our Full Range of Sequencing Services & Multi-Omic Technologies
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