Precision Capture & High-Throughput Omics Solutions
Accelerating discovery with automated target enrichment, high-fidelity sequencing, and quantitative molecular extraction platforms.
The Fundamental Role of Capture Efficiency in Proteomics & Metabolomics
In modern molecular biology and systems medicine, capturing the entire dynamic range of biological analytes represents the core technical bottleneck. High-throughput genomics has evolved rapidly, yet cellular phenotypic execution is governed directly by the functional proteome and the downstream metabolome. Achieving superior capture efficiency is no longer merely a metric of recovery yield; it is the definitive determinant of biological resolution, reproducibility, and translational clinical utility.
In untargeted and targeted mass spectrometry-based proteomics, peptide loss during sample homogenization, enzymatic digestion, desalting, and chromatographic fractionation drastically limits the detection of low-abundance regulatory proteins—such as transcription factors, signaling kinases, and cytokine mediators. Similarly, metabolomics grapples with extreme chemical diversity, spanning hydrophobic lipids, volatile organic compounds, and highly polar carbohydrates. Maximizing capture efficiency requires a concerted synergy between micro-scale solid-phase extraction (SPE), surface-functionalized magnetic nanoparticles, and intelligent thermodynamic elution matrices.
Overcoming Dynamic Range Bottlenecks
Biological fluids such as human plasma exhibit a dynamic protein concentration range exceeding 10 orders of magnitude. High-abundance proteins like serum albumin and immunoglobulins routinely mask vital diagnostic biomarkers.
• Nanoparticle Surface Engineering: Tailored coronas for selective low-abundance analyte enrichment.
• Automated Fluidic Extraction: Minimizing manual pipetting variance and non-specific vessel binding.
• Multi-Modal Fractionation: Orthogonal separation delivering comprehensive proteome coverage.
Optimized capture protocols routinely boost peptide identification depth by 300% to 500% compared to traditional non-depleted precipitation workflows.
Biomarker Technologies (BMK)
Global leader in multi-omics innovation, high-throughput sequencing, and advanced bioinformatics algorithms.
Biomarker Technologies (BMKGene), founded in 2009, is a leading genomics service provider with over 16 years of continuous innovation in high-throughput sequencing and bioinformatics. Backed by more than 60 national invention patents and 200+ software copyrights, we deliver comprehensive multi-omics solutions—spanning genomics, metagenomics, epigenetics, single-cell omics, transcriptomics, and our proprietary BMKMANU S3000 spatial transcriptome technology—supported by our advanced BMKCloud bioinformatics platform. We have established long-term collaborations with organizations across 84 regions worldwide, providing reliable genomic solutions on a global scale.
Our Platforms
State-of-the-art analytical instrumentation and bioinformatic computational power.
High-Throughput Sequencing & Mass Spectrometry
PacBio platforms: Sequel II, Sequel, RSII
Nanopore platforms: PromethION P48, GridION X5 MinION
10X Genomics: 10X ChromiumX, 10X Chromium Controller
Illumina platforms: NovaSeq
BGI-sequencing platforms: DNBSEQ-G400, DNBSEQ-T7
Bionano Irys system
Waters XEVO G2-XS QTOF
QTRAP 6500+
Over 20,000 square feet place
Advanced biomolecular laboratory instruments
Standard labs of sample extraction, library construction, clean rooms, sequencing labs
Standard procedures from sample extraction to sequencing under strict SOPs
Reliable, Ease-to-use Bioinformatic Platform
Self-developed BMKCloud platform
CPUs with 41,104 memory and 3 PB total storage
4,260 computing cores with peak computing power over 121,708.8 Gflop per second.
Commercial & Industrial Landscape: High-Efficiency Omics in Pharma & Agriculture
The biopharmaceutical industry has reached an inflection point where genomics alone cannot explain therapeutic escape mechanisms, off-target drug toxicities, or post-translational modulations. Pharmaceutical drug discovery workflows now mandate robust quantitative proteomics and targeted metabolomics pipelines. In antibody-drug conjugate (ADC) characterization, proteolysis targeting chimeras (PROTACs), and cell therapies, verifying target engagement requires the detection of protein degradation kinetics at femtomolar concentrations.
Simultaneously, agricultural biotechnology utilizes capture-efficient metabolomic fingerprinting to decode crop resilience traits, secondary metabolite biosynthesis under climate stress, and soil rhizosphere interactions. By combining high-efficiency automated magnetic extraction kits with cutting-edge tandem mass spectrometry (such as the Waters XEVO G2-XS QTOF and AB SCIEX QTRAP 6500+), researchers can resolve isobaric metabolic isomers and fragile signaling lipids that are typically lost during conventional preparation protocols.
Targeted Metabolite Recovery
Optimized quenching protocols capture transient metabolic intermediates, preventing ex vivo enzymatic degradation in physiological samples.
Spatial & Single-Cell Depth
Integration with BMKMANU S3000 spatial transcriptomics creates spatially resolved maps connecting RNA transcription to localized protein abundance.
Key Quality Attributes in Industrial Omics
• Coefficient of Variation (CV): < 5% across automated multi-well extraction batches.
• Cross-Matrix Linearity: Dynamic linear quantification across plasma, plant tissue, and bio-fermentation broths.
• High-Throughput Turnaround: Full library preparation cycles reduced by 60% through automated robotic integration.
Fully Automated Platform for Next-generation sequencing--Brilliant Lab 1000
Biomarker technologies (BMKGENE) and PerkinElmer have jointly built a fully automated experimental production line, called Brilliant Lab 1000 (BL1000), which is applied to the high-throughput NGS library construction service.
BMKGENE strives to greatly improve the entire line of sequencing products in terms of product types, production line throughput, delivery quality, and cycle time, to provide customers with better sequencing services.
Automated Facility & Experimental Operations
High-standard cleanrooms, automated liquid handlers, and molecular extraction suites.
Advanced Multi-Omics Application Scenarios
Translating sample capture efficiency into actionable biomedical discoveries and precision agricultural insights.
Exosomal Biomarker Profiling
Exosomes and extracellular vesicles (EVs) carry vital microRNA, proteomic cargoes, and metabolic signaling entities. Utilizing high-efficiency immuno-affinity and membrane-affinity capture protocols allows isolation of ultra-pure vesicle fractions from human biofluids with minimal cellular debris contamination, enabling early-stage oncology diagnostics.
Pharmacometabolomics & ADME
During preclinical drug candidate screening, capture efficiency governs the accurate quantification of drug metabolites and endogenous biochemical pathway shifts. High-resolution QTOF and QTRAP mass spectrometry platforms ensure complete molecular coverage from polar hydrophilic metabolites to non-polar membrane lipids.
AI-Driven Data Deconvolution
BMKCloud integrates proprietary machine learning algorithms to correct batch variations, align retention times across multi-batch LC-MS/MS runs, and perform automated MS2 fragment spectral matching against over 500,000 reference compound libraries, accelerating compound annotation accuracy.
Future Perspectives: Next-Gen Nanopore & Single-Molecule Proteomics
As life sciences transition toward single-molecule protein sequencing and real-time metabolic flux analysis, the physical boundaries of capture efficiency are being redefined. Microfluidic partition systems, paired with targeted magnetic bead capture matrices (such as the TGuide Smart series), provide the foundational purity required for long-read sequencing platforms (PacBio Sequel II, Oxford Nanopore PromethION) and high-sensitivity mass spectrometers. Biomarker Technologies remains at the vanguard of this revolution, merging proprietary automated instruments with deep multi-omics bioinformatic intelligence.
Enterprise Qualifications & Research Stations
National recognition, collaborative academic workstations, and international quality management standards.
Patents & Software Copyrights
Proprietary technological breakthroughs in extraction chemistry, sequence assembly, and bioinformatic pipelines.
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