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Small Intestinal Multi-Omics Identifies Candidate Biomarkers of Obesity and Obesity Resistance
Featured Publication Small Intestinal Multi-Omics Identifies Candidate Biomarkers of Obesity and Obesity Resistance Integrated microbiome, metabolomic, and transcriptomic analyses reveal distinct molecular signatures associated with susceptibility and resistance to diet-induced obesity in mice...Read more -
Spatio-DARLIN Enables In Situ Lineage Tracing at Single-Cell Resolution
Featured Publication Spatio-DARLIN Enables In Situ Lineage Tracing at Single-Cell Resolution A spatial lineage-tracing method jointly captures clonal origin, transcriptomic state, and tissue location to resolve developmental dynamics in the mouse intestine and brain. Journal: Nature Methods Ye...Read more -
Transcriptomic Insights into Trichothecene Mycotoxin-Induced Ribotoxic Stress
Featured Publication Mapping the Dynamic Cellular Response to Trichothecene Mycotoxins Time-course RNA sequencing reveals rapid stress-pathway activation, strong histone gene upregulation, and distinct longer-term responses to translation inhibition. Journal: Archives of Toxicology Year: 20...Read more -
Cancer Cell-Derived Collagens Form Physical Barriers Linked to Immunotherapy Resistance in NSCLC
Featured Publication Cancer Cell-Derived Collagens Form Physical Barriers Linked to Immunotherapy Resistance in NSCLC Integrated single-cell RNA sequencing, spatial transcriptomics, and proteomics reveal how tumor cell-derived collagens may limit T-cell access and contribute to acquired imm...Read more -
Host Species Identity Shapes Early-Life Gut Microbiota in Sympatric Wild Raptors
Featured Publication Host Species Identity Shapes Early-Life Gut Microbiota in Sympatric Wild Raptors 16S rRNA gene profiling of white-tailed and lesser spotted eagle nestlings reveals species-specific microbial communities, contrasting predicted functions, and substantial individual variat...Read more -
Linking B Chromosomes to Plant Invasiveness at Single-Cell Resolution
Featured Publication Linking B Chromosomes to Plant Invasiveness at Single-Cell Resolution Integrated single-cell, spatial, and comparative genomic analyses reveal cell type-specific transcriptional differences and expanded B-chromosome copy numbers in invasive North American populations of...Read more -
Uncovering a Proangiogenic circNPHP1 Network in Ischemic Heart Disease
Featured Publication Uncovering a Proangiogenic circNPHP1 Network in Ischemic Heart Disease Human left ventricular transcriptomics and endothelial-cell validation reveal a circNPHP1–miR-221-3p–VEGFA/BCL2 regulatory axis that supports angiogenesis under ischemic and diabetic conditions. Jour...Read more -
DPF2 Links Chromatin Remodeling to Macrophage-Driven Intestinal Inflammation
Featured Publication DPF2 Links Chromatin Remodeling to Macrophage-Driven Intestinal Inflammation Integrated genetic, single-cell, spatial, epigenomic, and clinical analyses reveal how the DPF2–CACNA1D–calcium–MAPK axis shapes macrophage polarization, intestinal inflammation, and tissue reg...Read more -
Multi-Omics Insights into SBE-Mediated Regulation of Acute Oxidative Stress
Featured Publication Multi-Omics Insights into SBE-Mediated Regulation of Acute Oxidative Stress Integrated microbiome, metabolomic, and transcriptomic analyses reveal how Sonchus brachyotus DC. extract may influence gut microbial communities, host metabolites, and apoptosis-related signali...Read more -
Six Telomere-to-Telomere Peanut Genomes Reveal Evolutionary Dynamics and Breeding Targets
Featured Publication Six Telomere-to-Telomere Peanut Genomes Reveal Evolutionary Dynamics and Breeding Targets High-quality reference genomes and population resequencing of 521 accessions uncover subgenome asymmetry, domestication-associated structural variation, and candidate genes linked ...Read more -
Revealing the CSF1R–PPARα Axis in Psoriatic Inflammation
Featured Publication Revealing the CSF1R–PPARα Axis in Psoriatic Inflammation Integrated single-cell, spatial, and bulk transcriptomic analyses identify pathogenic CSF1R-high mononuclear phagocyte system hubs and reveal how systemic CSF1R targeting may promote the resolution of inflammation...Read more -
Decoding the Complex Polyploid Genome of Modern Sugarcane
Featured Publication Decoding the Complex Polyploid Genome of Modern Sugarcane A haplotype-resolved genome assembly provides new insights into sugarcane genome evolution, subgenome divergence, breeding history, and agronomically important traits. Journal: Nature Genetics Year: 2025 Volume 5...Read more -
Dietary Fibre Shapes Host Immunity During Chronic Gut Parasite Infection
Featured Publication Dietary Fibre Shapes Host Immunity During Chronic Gut Parasite Infection A recent study reveals how purified inulin fibre can directly and time-dependently modulate mucosal immunity during chronic parasitic infection. Journal: Microbiome Year: 2026 Volume 14 · Article 57...Read more
