Groundbreaking research reveals how our gut bacteria produce serotonin and shape our nervous system!
A new study in Cell Reports has pinpointed 20 human gut commensals—including Klebsiella aerogenes, Morganella morganii, and several Clostridia species—that convert 5-HTP into bioactive serotonin.
These “serotonin-making bugs” were found to:
✅ Carry a conserved tryptophan decarboxylase operon
✅ Promote a 35% denser network of enteric neurons in mice
✅ Accelerate colonic motility via the 5-HT4 receptor
✅ Act as local endocrine factories, sculpting the enteric nervous system
The findings open doors to potential probiotic or dietary strategies for constipation, post-operative ileus, and even mood-motility disorders—adding a whole new microbial dimension to the gut–brain axis!
We’re proud to have provided RNA sequencing services and bioinformatics analysis for this exciting work
Post time: Jan-26-2026
