Case Study | Single Nucleus RNA-Seq Uncovers New Mechanisms in Diabetic Angiopathy
A team recently published a study in Redox Biology titled “Translocation of SIRT6 promotes glycolysis reprogramming to exacerbate diabetic angiopathy.”
Here’s what they found: high glucose and lipids boost ROS levels in vascular smooth muscle cells (VSMCs), which pushes SIRT6 out of the nucleus and into the cytoplasm. Once there, cytoplasmic SIRT6 grabs onto a glycolytic enzyme called ENO3, deacetylates it, and cranks up its activity – triggering a harmful shift in glycolysis.
The good news? Adding hydrogen sulfide (H₂S) lowers oxidative stress, adds a sulfur group to SIRT6 at cysteine 141, blocks the SIRT6–ENO3 interaction, and helps restore normal glycolysis and VSMC function in diabetic angiopathy.
BMKGENE provided RNA-seq and single nucleus RNA sequencing for this study.
Post time: Apr-14-2026
