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Full-Length mRNA-Seq Product & Company in France

Advancing Transcriptomics with Long-Read Sequencing Solutions for Clinical, Industrial, and Agricultural Research

Featured Genomic Sequencing Services

Explore our primary high-throughput sequencing and transcriptomics solutions designed to deliver high-resolution biological insights.

Human Whole Exome Sequencing

Comprehensive coding region analysis for identifying disease-associated genetic variants and mutations.

CircRNA Sequencing-Illumina

High-throughput sequencing optimized for identifying and profiling non-coding circular RNAs.

TGuide Smart Blood Genomic DNA Kit

Automated, high-efficiency purification system for high-quality genomic DNA extraction from blood samples.

circ-RNA

Advanced bioinformatic analysis suite for structural characterization of circular RNA molecules.

The Rise of Full-Length mRNA-Seq in France

In the landscape of modern molecular biology, Full-Length mRNA Sequencing (mRNA-Seq) has emerged as a transformative technology. Traditional short-read sequencing techniques often shear RNA molecules, requiring complex computational assembly that can lead to errors and ambiguity in isoform identification. In contrast, Full-Length mRNA-Seq leverages long-read sequencing technologies, such as Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT), to sequence intact RNA molecules from end to end. This provides unprecedented resolution of the transcriptome, enabling researchers to identify precise transcript isoforms, alternative splicing events, fusion genes, and allele-specific expressions without the need for fragment assembly.

France has established itself as a leading force in European biotechnology and life sciences. Backed by public initiatives such as the "France 2030" investment plan, which prioritizes healthcare innovation and biotherapies, the demand for cutting-edge genomic technologies has surged. Academic research hubs in Paris-Saclay, Lyon, Marseille, and Toulouse, alongside major national institutes like INSERM, CNRS, and INRAE, are increasingly integrating full-length transcriptomics to accelerate discoveries in oncology, immunology, rare diseases, and agricultural biotechnology.

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Key Advantages of Long-Read RNA-Seq

Complete Isoform Resolution: Capture complete 5' to 3' transcript structures, resolving complex alternative splicing patterns.

Alternative Polyadenylation (APA): Accurately identify polyadenylation sites, crucial for post-transcriptional regulation studies.

Fusion Gene Detection: Identify chimeric transcripts and gene fusions with high confidence, essential for oncology research.

Direct RNA Sequencing: Sequence native RNA molecules directly, preserving critical epigenetic modifications (e.g., m6A).

Localized Application Scenarios in the French Biotech Ecosystem

From clinical oncology in Parisian research hospitals to crop resistance studies in the agricultural plains of France, Full-Length mRNA-Seq is redefining scientific research.

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Oncology & Personalized Medicine

In French clinical research centers like the Gustave Roussy and Curie Institutes, characterizing the cancer transcriptome is vital. Tumor cells frequently exhibit dysregulated splicing, producing neoantigens that drive progression. Full-length mRNA-Seq allows oncology researchers to profile cancer-specific isoforms, paving the way for personalized mRNA vaccines and targeted immunotherapies.

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Agricultural Biotechnology (AgriTech)

As Europe's leading agricultural producer, France relies heavily on crop innovation. Collaborating with organizations like INRAE, researchers utilize full-length sequencing to study crop transcriptomes under environmental stress. Identifying full-length transcripts in crops like wheat, barley, and grapes aids in breeding resilient varieties capable of withstanding climate change and pathogens.

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Rare Disease & Splicing Therapeutics

Over 3 million people in France are affected by rare diseases, many of which are genetic. Traditional exome sequencing often fails to detect deep intronic mutations that alter splicing. Full-length transcriptomics identifies aberrant splicing events directly, providing diagnostic answers and identifying novel targets for antisense oligonucleotide (ASO) therapies.

Market Trends & Sourcing Full-Length mRNA-Seq in France

The commercial market for genomic services in France is undergoing a transition. Historically, French institutions relied on local core facilities or centralized academic platforms. However, the scale and complexity of modern multi-omics projects require industrial-grade throughput, strict quality controls, and rapid turnaround times. This has driven a shift towards partnership with specialized global genomics providers that maintain state-of-the-art sequencing fleets and automated workflows.

Another major trend is the integration of transcriptomics with other omics layers, such as proteomics and single-cell spatial transcriptomics. As companies develop complex biopharmaceuticals, understanding the direct link between gene expression, isoform variation, and protein translation is critical. Consequently, service providers offering unified multi-omics pipelines, integrated bioinformatics cloud platforms, and comprehensive regulatory compliance are highly favored by French pharmaceutical R&D divisions and clinical-stage biotech startups.

Biomarker Technologies (BMKGene)

Biomarker Technologies (BMKGene), founded in 2009, is a leading genomics service provider with over 16 years of continuous innovation in high-throughput sequencing and bioinformatics. Backed by more than 60 national invention patents and 200+ software copyrights, we deliver comprehensive multi-omics solutions—spanning genomics, metagenomics, epigenetics, single-cell omics, transcriptomics, and our proprietary BMKMANU S3000 spatial transcriptome technology—supported by our advanced BMKCloud bioinformatics platform. We have established long-term collaborations with organizations across 84 regions worldwide, providing reliable genomic solutions on a global scale.

Our commitment to excellence aligns with the stringent standards required by French and European research institutions. By offering highly optimized workflows for PacBio and Oxford Nanopore platforms, BMKGene provides French researchers with robust, publication-ready full-length mRNA-Seq data, backed by customizable bioinformatics pipelines on BMKCloud.

Multiple and flexible experimental designs fulfilling diverse research goals

Our Advanced Sequencing Platforms & Facilities

We host a comprehensive range of cutting-edge molecular biology and sequencing infrastructure to support diverse research scales.

Leading, Multi-level High-throughput Sequencing Platforms

High-Throughput Platforms

PacBio platforms: Sequel II, Sequel, RSII

Nanopore platforms: PromethION P48, GridION X5 MinION

10X Genomics: 10X ChromiumX, 10X Chromium Controller

Illumina platforms: NovaSeq

BGI-sequencing platforms: DNBSEQ-G400, DNBSEQ-T7

Bionano Irys system

Waters XEVO G2-XS QTOF

QTRAP 6500+

Professional, Automatic Molecular Laboratory

Over 20,000 sq. ft. Facility

Advanced biomolecular laboratory instruments.

Standardized laboratories for sample extraction, library construction, clean rooms, and sequencing labs.

Standard operating procedures (SOPs) applied from sample extraction to sequencing to ensure maximum reproducibility.

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BMKCloud Bioinformatic Analysis

Self-developed BMKCloud platform offering dynamic, user-friendly data analysis interfaces.

Equipped with CPUs featuring 41,104 memory and 3 PB total storage capacity.

4,260 computing cores delivering peak computing power over 121,708.8 Gflop per second.

Fully Automated Platform for Next-Generation Sequencing: Brilliant Lab 1000

Biomarker Technologies (BMKGENE) and PerkinElmer have jointly built a fully automated experimental production line, called Brilliant Lab 1000 (BL1000), which is applied to high-throughput NGS library construction services.

BMKGENE strives to greatly improve the entire line of sequencing products in terms of product types, production line throughput, delivery quality, and cycle time, to provide customers with better sequencing services. Through automation, we minimize manual pipetting errors, reduce batch-to-batch variation, and accelerate project delivery for large-scale clinical trials and crop genomics projects in France and globally.

Enterprise Qualification & Research Credentials

BMKGene maintains the highest standards of scientific rigor and operational quality, validated by international certifications and academic partnerships.