Alaabta

Falanqaynta Ururka Genom-ballaaran

Daraasada ururka genome-wide (GWAS) waxay ujeedadeedu tahay in lagu aqoonsado kala duwanaanshaha hidde-sideyaasha (genotype) ee la xidhiidha sifooyin gaar ah (phenotype).Daraasada GWAS waxay baartaa calaamadaha hidde-sidaha oo ka gudba genome-ga tiro badan oo shakhsiyaad ah waxayna saadaalisaa ururada genotype-phenotype iyadoo la adeegsanayo falanqaynta tirakoobka ee heerka dadweynaha.Waxaa si weyn loogu dabaqay cilmi-baaris ku saabsan cudurrada bini'aadamka iyo macdanta hidda-socodka ee shaqeynaya ee sifooyinka adag ee xayawaanka ama dhirta.

Nala soo xiriir

Faahfaahinta Adeegga

Natiijada Demo

Daabacaada sifada

1. Faa'iidooyinka Adeegga

Kiisaska Mashruuca Badan: tan iyo markii la aasaasay 2009, BMKGENE waxay dhamaystirtay boqollaal mashruuc oo noocyo ah oo ku saabsan cilmi-baarista GWAS ee dadweynaha, waxay caawisay cilmi-baarayaasha si ay u daabacaan in ka badan 100 maqaal, iyo saameynta isugeynta waxay gaartay 500.
● Falanqeeyayaasha xirfadlayaasha ah.
● Wareegga falanqaynta gaaban.
● Macdanta xogta saxda ah.

2. Tilmaamaha Adeegga

Nooca	Qiyaasta Dadweynaha	Istaraatiijiyada isku xigxiga iyo qoto dheer
SAF-GWAS	Tusaalaha nambarka ≥200	Cabbirka genome <400M, oo leh ref-genome, WGS ayaa lagula talinayaa
		Cabbirka Genome ≤ 1G, 100K Tags iyo 10X
		1G ≤ Cabbirka Genome ≤ 2G, 200K Tags iyo 10X
		Cabbirka genome>2G, 300K Tags iyo 10X
WGS-GWAS	Tusaalaha nambarka ≥200	10X muunad kasta

3. Xulashada agabka

Noocyo kala duwan, nooc-hoosaadyo, dhul-beereedka/bangiyada hidde-sideyaasha/qoysaska isku-dhafan/khayraadka duur-joogta

Noocyada kala duwan, noocyada kala duwan, dhul-beereedka

Qoyska badh-sib/qoyska-sib-buuxa/khayraadka duurjoogta

4. Falanqaynta Xogta Noolaha

● Falanqaynta ururka genome-ballaaran
● Falanqaynta iyo baadhista SNP ee muhiimka ah
● Sharaxaada hawleed ee hidda-wadaha murashaxa

5. Socodka Shaqada Adeegga

Naqshadaynta tijaabada

Tusaalaha keenista

soo saarista RNA

Dhismaha maktabadda

Isku xigxiga

Falanqaynta xogta

Adeegyada iibka kadib

Hore: Isku-dabaynta hal-xuduneed ee RNA

Xiga:

a.Phenotype QC

Histogram qaybinta inta jeer

Tirakoobka Phenotype

b.Falanqaynta ururka (Model: GEMMA, FaST-LMM, EMMAX)

Shirqoolkii QQ

Shirqoolkii Manhattan

Sannadka	Joornaal	IF	Ciwaanka
2022	NC	17.69	Asalkii asalka ahaa ee koromosoomyada giga-chromosomes iyo giga-genome of peony Peony Paeonia ostii
2015	NP	7.43	Raad-raacyada gurigu waxay ku xidhaan gobollada genomic ee muhiimadda beeralayda ee digirta
2018	MP	9.32	Isku soo wada duuboo genome-ga guud ee u ekaanshaha ururinta abuuritaanka kufsiga ee adduunka oo dhan ayaa daaha ka qaadaya aasaaska hidde-sidaha kala duwanaanshaha deegaankooda.
2022	HR	7.29	Falanqaynta ururrada guud ee genome waxay bixisaa aragtiyo molecular ee kala duwanaanshaha dabiiciga ah ee cabbirka iniinaha qaraha