Featured Spatial & NGS Solutions
Pioneering Spatial Transcriptomics in Tokyo's Research Ecosystem
Tokyo has solidified its position as a global epicentre for biomedical research and industrial biotechnology. With key hubs such as the Nihonbashi Life Science district, the University of Tokyo, Tokyo Institute of Technology, and the RIKEN Center for Integrative Medical Sciences, the metropolitan area is at the forefront of driving spatial biology innovations. Researchers and pharmaceutical corporations in Tokyo are rapidly transitioning from bulk RNA sequencing to single-cell and spot-based spatial transcriptomics to dissect the complex cellular architectures of tissues.
By utilizing spot-based spatial transcriptomics, laboratories in Tokyo can now map gene expression profiles directly onto histological tissue sections. This approach retains vital spatial coordinates, enabling scientists to identify how cells communicate within their native microenvironments. This is particularly crucial for oncology, immunology, and neurodegenerative disease research, which are major pillars of Japan’s national medical research strategy.
Local Industrial Significance
Japan's pharmaceutical giants and clinical research organizations (CROs) located in Tokyo are actively adopting spot-based technology for drug target discovery, biomarker validation, and toxicity profiling. The integration of high-resolution spatial transcriptomics accelerates preclinical workflows, reducing the time-to-market for novel therapeutic agents.
Key Trends and Localized Applications in Japan
The adoption of spatial biology in Japan is scaling rapidly, driven by advanced imaging technologies, high-throughput sequencing pipelines, and AI-driven bioinformatics tools.
Oncology & Immunotherapy
Tokyo's leading cancer research institutes utilize spatial transcriptomics to explore the tumor microenvironment (TME). By mapping immune cell infiltration relative to tumor margins in gastric and lung cancers, researchers can better predict patient responses to immune checkpoint inhibitors.
Neuroscience Research
With Japan's super-aging society, neurodegenerative diseases like Alzheimer's and Parkinson's are major research priorities. Spot-based transcriptomics allows researchers in Tokyo to map gene expression changes in specific brain regions, identifying localized pathological mechanisms.
Agricultural Genomics
Institutions in the Kanto region apply spatial transcriptomics to plant sciences. Mapping the spatial distribution of transcripts in crop leaves and roots helps develop drought-resistant and high-yield crops, securing agricultural sustainability.
About Biomarker Technologies (BMKGene)
Biomarker Technologies (BMKGene), founded in 2009, is a leading genomics service provider with over 16 years of continuous innovation in high-throughput sequencing and bioinformatics. Backed by more than 60 national invention patents and 200+ software copyrights, we deliver comprehensive multi-omics solutions—spanning genomics, metagenomics, epigenetics, single-cell omics, transcriptomics, and our proprietary BMKMANU S3000 spatial transcriptome technology—supported by our advanced BMKCloud bioinformatics platform. We have established long-term collaborations with organizations across 84 regions worldwide, providing reliable genomic solutions on a global scale.
Our commitment to quality, speed, and scientific precision has made us a trusted partner for universities, pharmaceutical firms, and research laboratories throughout Tokyo and the wider Japanese market.
Our Leading Multi-level High-throughput Sequencing Platforms
BMKGene operates state-of-the-art sequencing and bioinformatics platforms, ensuring that researchers in Tokyo receive industry-leading data resolution and turnaround times.
PacBio & Nanopore Platforms
PacBio platforms: Sequel II, Sequel, RSII
Nanopore platforms: PromethION P48, GridION X5, MinION
10X Genomics: 10X ChromiumX, 10X Chromium Controller
Illumina platforms: NovaSeq
BGI-sequencing platforms: DNBSEQ-G400, DNBSEQ-T7
Additional Systems: Bionano Irys system, Waters XEVO G2-XS QTOF, QTRAP 6500+
Over 20,000 Square Feet Laboratory
Our professional, automatic molecular laboratory features advanced biomolecular laboratory instruments.
We host standard labs for sample extraction, library construction, clean rooms, and sequencing labs.
Standard procedures from sample extraction to sequencing are executed under strict SOPs to ensure reproducibility and high-quality outputs.
Reliable, Easy-to-use BMKCloud
Our self-developed BMKCloud bioinformatics platform empowers researchers with seamless data analysis capabilities.
Equipped with CPUs featuring 41,104 memory and 3 PB total storage.
Boasts 4,260 computing cores with peak computing power exceeding 121,708.8 Gflop per second.
Fully Automated Platform for Next-generation Sequencing: Brilliant Lab 1000
Biomarker technologies (BMKGENE) and PerkinElmer have jointly built a fully automated experimental production line, called Brilliant Lab 1000 (BL1000), which is applied to the high-throughput NGS library construction service.
BMKGENE strives to greatly improve the entire line of sequencing products in terms of product types, production line throughput, delivery quality, and cycle time, to provide customers with better sequencing services.
This automation setup dramatically reduces manual pipetting errors, standardizes spatial transcriptomics library prep, and guarantees that samples processed for Tokyo researchers meet the highest international standards of genomic integrity.
Enterprise Qualifications & Global Certifications
Our dedication to excellence is certified by international standards and backed by dozens of proprietary patents in molecular biology and cloud computing.
Patents & Software Copyrights
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