BMKGENE e fane ka tatellano ea nako e telele ea nanopore RNA ea ONT le tšebeletso ea ATAC-seq bakeng sa thuto "Epigenetic le transcriptal activation of secretory kinase FAM20C as an oncogene in glioma", e hatisitsoeng ho 《Journal of Genetics and Genomics》.
Boithuto bona bo thehile atlase ea bolelele bo felletseng ka li-glioma tse palaneng mme e hlokometse hore liphatsa tsa lefutso tse 22 li laoloa ke tlhahlobo ea bolelele bo felletseng le tlhahlobo ea APA.Tlhahlobo ea data ea ATAC-seq e senola hore bobeli FAM20C le NPTN ke liphatsa tsa lefutso tse nang le ho buleha ha chromatin le polelo e fapaneng.
Ho feta moo, lithuto tsa in vitro le in vivo li fana ka maikutlo a hore FAM20C e hlohlelletsa ho ata le metastasis ea lisele tsa glioma.Ho sa le joalo, NPTN, mofuta o mocha oa khatello ea mofetše, o hanana le ts'ebetso ea FAM20C ka ho thibela ho ata le ho falla ha glioma.Ho thibeloa ha FAM20C ka ho fokotsa li-antibodies ho fella ka ho fokotseha ha lihlahala tsa xenograft.Ho feta moo, MAX, BRD4, MYC, le REST li fumanoa e le lintlha tse ka bang teng tsa trans-active bakeng sa taolo ea FAM20C.
Ha li kopane, liphetho tsena li senola karolo ea oncogenic ea FAM20C ho glioma le ho fana ka leseli le lecha mabapi le kalafo ea glioma ka ho felisa FAM20C .
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Nako ea poso: Oct-20-2023