BMKGENE e fane ka lits'ebeletso tse ngata tsa tatellano le tlhahlobo ea RNA bakeng sa thuto ena: Li-adipocyte tse kenang ka maqeba ha se myofibroblasts.
Sengoliloeng se phatlalalitsoe ho Nature Communications, se hlahloba polasetiki e ka bang teng ea adipocytes le fibroblasts kamora ho tsoa kotsi ea letlalo.U sebelisa liphatsa tsa lefutso ho latela le ho nahana ka bophelo ho li-explants le liphoofolong tse lemetseng, hlokomela hore kotsi e etsa hore boemo ba nakoana ba ho falla ho adipocyte bo nang le mekhoa e fapaneng ea ho falla ha lisele le boitšoaro bo tsoang ho fibroblasts.
Ho feta moo, li-adipocyte tse fallang, ha li kenye letsoho ho theheng lebali 'me li lula li se na fibrogenic in vitro, in vivo, le ha li fetisetsoa maqeba liphoofolong.Ka bokhutšoanyane, li-adipocyte tse fallang tse bakoang ke kotsi li lula li thibetsoe ke meloko 'me ha li fetohe kapa li hlophisa bocha ho fibrosing phenotype.Liphuputso tsena li ama ka ho pharaletseng maano a mantlha le a phetolelo lefapheng la meriana e nchafatsang, ho kenyeletsoa le mehato ea bongaka bakeng sa tokiso ea maqeba, lefu la tsoekere le fibrotic pathologies.
Tobetsa mona hoithute haholoanyane ka thuto ena
Nako ea poso: Aug-29-2023