ʻO ka methylation DNA kekahi o nā hoʻololi epigenetic i aʻo nui ʻia.He kuleana koʻikoʻi ia i ka paʻa ʻana o ka genome, ka hoʻoponopono transcription gene, a me ka hoʻomohala ʻana.Hoʻoholo ʻia ka transcription o nā genes e ko lākou kūlana methylation, me nā haʻahaʻa haʻahaʻa haʻahaʻa e pili ana me ka hōʻike gene a me nā pae methylation kiʻekiʻe e pili ana me ka silencing gene.
ʻO ka hoʻohui ʻana i ka holoʻokoʻa-genome bisulfite sequencing (WGBS) a me ka ʻikepili RNA-seq e hiki ai i ka nānā ʻana i ka genome a me ka transcriptome, e hōʻike ana i nā ʻano hoʻoponopono gene, a me ka ʻike ʻana i nā mīkini biological hou a me nā biomarkers.Hiki ke hoʻokumu ʻia ka hui ma waena o ka transcriptome a me ka methylation sequencing data ma muli o nā genes, e hoʻohui i nā ʻikepili ʻelua me ka hoʻohana ʻana i nā genes ma ke alahaka.
Kōkua kēia ʻimi noiʻi e hoʻomaopopo i ka pilina ma waena o ka methylation DNA a me ka hōʻike ʻana, e ʻike i nā genes i hoʻopili ʻia e ka methylation, a e noiʻi i nā hopena hana o lalo.
E ʻoluʻolu e kelepona iā BMKGENE no nā ʻike like ʻole i ka noiʻi epigenetic.
Ka manawa hoʻouna: Dec-05-2023