I-DNA methylation ingenye yezinguquko ze-epigenetic ezifundwe kabanzi.Idlala indima ebalulekile ekuzinzeni kofuzo, ekulawuleni ukulotshwa kofuzo, nasekuthuthukisweni kwesici.Ukubhalwa kwezakhi zofuzo kunqunywa isimo sabo se-methylation, namazinga aphansi e-methylation ahlotshaniswa ne-gene expression kanye namazinga aphezulu e-methylation ahambisana nokuthuliswa kwezakhi zofuzo.
Ukuhlanganisa i-whole-genome bisulfite sequencing (WGBS) kanye nedatha ye-RNA-seq kuvumela ukuhlaziywa okuphelele kwe-genome ne-transcriptome, ukuveza izindlela zokulawula izakhi zofuzo, kanye nokuhlonza izindlela ezintsha zebhayoloji nama-biomarker.Ukuhlangana phakathi kwedatha yokulandelana kwe-transcriptome kanye ne-methylation kungasungulwa ngokusekelwe kuzakhi zofuzo, kuhlanganiswe womabili amasethi edatha kusetshenziswa izakhi zofuzo njengebhuloho.
Lokhu kuhlaziya kusiza ukuqonda ukuhlobana phakathi kwe-DNA methylation kanye nokuchazwa kofuzo, ukuhlonza izakhi zofuzo ezithonywa i-methylation, futhi kuphenye imiphumela yokusebenza engezansi.
Zizwe ukhululekile ukuxhumana ne-BMKGENE ukuze uthole imininingwane engenakuqhathaniswa ocwaningweni lwe-epigenetic.
Isikhathi sokuthumela: Dec-05-2023