I-BMKGENE inikeze izinsiza zokulandelanisa nokuhlaziya i-RNA kulolu cwaningo “I-Aspergillus fumigatus iduna i-p11 yomuntu ukuze iqondise kabusha ama-phagosome aqukethe ukhunta endleleni engawonakali.", eyashicilelwa ku-Cell Host & Microbe.
Isinqumo sokuthi ama-endosomes angena endleleni eyonakalisayo noma egaywa kabusha kumaseli ezilwane ezincelisayo sibaluleke kakhulu ekubulaweni kwe-pathogen, futhi ukungasebenzi kahle kwayo kunemiphumela yokugula.
Lolu cwaningo luthole ukuthi i-p11 yomuntu iyisici esibalulekile kulesi sinqumo.Iphrotheni ye-HscA ekhona endaweni eyi-condial yesikhunta se-human-pathogenic i-Aspergillus fumigatus anchors p11 kuma-conidia-containing phagosomes (PSs), ayifaki umlamuli wokuvuthwa we-PS u-Rab7, futhi ibangela ukubopha kwabaxhumanisi be-exocytosis i-Rab11 ne-Sec15.Lokhu kuhlelwa kabusha kuqondisa kabusha ama-PSs endleleni engawonakali, okuvumela i-A. fumigatus ukuthi ibaleke amaseli ngokukhula nokuxoshwa kanye nokudluliswa kwe-conidia phakathi kwamaseli.
Ukufaneleka komtholampilo kusekelwa ukuhlonza i-nucleotide polymorphism eyodwa endaweni engafaki ikhodi ye-S100A10 (p11) isakhi sofuzo esithinta i-mRNA kanye nokubonakaliswa kwamaprotheni ekuphenduleni kwe-A. fumigatus futhi kuhlotshaniswa nokuvikelwa ngokumelene ne-aspergillosis yamaphaphu.Lokhu okutholakele kuveza indima ye-p11 ekulamuleni ukubalekela ifungal PS.
Chofozalaphaukuze ufunde kabanzi mayelana nalesi sihloko.
Isikhathi sokuthumela: Sep-08-2023