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Nanopore Inyandiko-mvugo yuzuye
Isoforms igoye kandi ihindagurika mubindi binyabuzima nuburyo bwingenzi bwo kugenzura imiterere ya gene hamwe na poroteyine zitandukanye.Kumenya neza inyandiko-mvugo ni ishingiro ryokwiga byimbitse uburyo bwo kugenzura imiterere ya gene.Ikurikiranyabihe rya Nanopore ryazanye neza inyandiko-mvugo kuri isoform-urwego.Ihuriro ryisesengura ryakozwe kugirango dusesengure amakuru ya RNA-Seq yakozwe kuri platform ya Nanopore hashingiwe kuri genome yerekanwe, igera ku isesengura ryujuje ubuziranenge no mu rwego rwa gene ndetse no ku nyandiko-mvugo.
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Ubwihindurize
Ihuriro ryisesengura ryabaturage hamwe nubwihindurize ryashizweho hashingiwe ku bunararibonye bunini bwakusanyirijwe mu itsinda rya BMK R&D imyaka.Nigikoresho cyumukoresha igikoresho cyane cyane kubashakashatsi batiga bioinformatics.Ihuriro rituma ubwihindurize bwibanze bwihindagurika bujyanye nisesengura ryibanze harimo kubaka ibiti bya phylogeneque, guhuza indwara ya calcquilibrium, gusuzuma imiterere itandukanye, gusesengura ibintu, gusesengura ubuvandimwe, PCA, gusesengura imiterere yabaturage, nibindi.
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umuzenguruko-RNA
Umuzenguruko wa RNA (circRNA) ni ubwoko bwa RNA idafite code, iherutse kugaragara ko igira uruhare runini mu miyoboro igenzura igira uruhare mu iterambere, kurwanya ibidukikije, n'ibindi. Bitandukanye na molekile ya RNA, urugero nka mRNA, lncRNA, 3 ′ na 5 ′ Impera ya circRNA ihujwe hamwe kugirango ikore uruziga, ibarinda igogorwa rya exonuclease kandi irahagaze neza kuruta umurongo wa RNA.CircRNA yasanze ifite imirimo itandukanye muguhuza imvugo ya gene.CircRNA irashobora gukora nka ceRNA, ihuza miRNA kurushanwa, izwi nka miRNA sponge.Ihuriro ryisesengura rya CircRNA riha imbaraga imiterere ya RNA no gusesengura imvugo, guhanura intego hamwe no gusesengura hamwe nubundi bwoko bwa molekile ya RNA
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BSA
Isesengura ryinshi rya Segregant Isesengura rigizwe nintambwe imwe yisesengura risanzwe hamwe nisesengura ryambere hamwe nibisobanuro byihariye.BSA ni tekinike ikoreshwa kugirango imenye vuba ibimenyetso bya genoside bifitanye isano.Ibikorwa nyamukuru bya BSA birimo: 1. guhitamo amatsinda abiri yabantu bafite phenotypes zirwanya cyane;2. guhuriza hamwe ADN, RNA cyangwa SLAF-seq (Byakozwe na Biomarker) byabantu bose kugirango babe igice kinini cya ADN;3. kumenya itandukaniro ritandukanye na genome cyangwa hagati, 4. guhanura abakandida bahujwe na ED na SNP-indangagaciro ya algorithm;5. Isesengura ryimikorere no gutunganyiriza genes mu turere tw’abakandida, nibindi.
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Amplicon (16S / 18S / ITS)
Ihuriro rya Amplicon (16S / 18S / ITS) ryatejwe imbere nuburambe bwimyaka mu isesengura ryimishinga itandukanye ya mikorobe, ikubiyemo isesengura ryibanze ryibanze hamwe nisesengura ryihariye: isesengura ryibanze rikubiyemo isesengura ryibanze ryibintu bikubiye mubushakashatsi bwa mikorobe, ibisesengura birakungahaye kandi byuzuye, n'ibisubizo by'isesengura bitangwa muburyo bwa raporo z'umushinga;Ibiri mu isesengura ryihariye biratandukanye.Ingero zirashobora gutoranywa kandi ibipimo birashobora gushyirwaho byoroshye ukurikije raporo yibanze yisesengura nintego yubushakashatsi, kugirango tumenye ibisabwa byihariye.Sisitemu y'imikorere ya Windows, yoroshye kandi yihuse.
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Proteomics
Proteomics ikubiyemo ikoreshwa rya tekinoroji yo kugereranya poroteyine rusange zigaragaza ingirabuzimafatizo, ingirabuzimafatizo cyangwa ibinyabuzima.Tekinoroji ishingiye kuri poroteyine ikoreshwa mubushobozi butandukanye mubushakashatsi butandukanye nko kumenya ibimenyetso bitandukanye byo gusuzuma, abakandida ku nkingo, gusobanukirwa uburyo bwo gutera indwara, guhindura uburyo bwo kwerekana ibisubizo bitandukanye no gusobanura inzira za poroteyine zikora mu ndwara zitandukanye.Kugeza ubu, tekinoroji ya proteomics igizwe ahanini na TMT, Label Free na DIA ingamba zo kubara.
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Metabolomics
Metabolome nigicuruzwa cyanyuma cya genome kandi kigizwe nubwuzuzanye bwuzuye bwa molekile zose zifite uburemere buke (metabolite) muri selile, tissue, cyangwa organisme.Metabolomics igamije gupima ubugari bwa molekile ntoya murwego rwo gukangura umubiri cyangwa indwara.Uburyo bwa Metabolomics bugizwe mumatsinda abiri atandukanye: metabolomics idafite intego, isesengura ryuzuye ryisesengura ryapimwe murugero harimo imiti itazwi ikoresheje GC-MS / LC-MS, hamwe na metabolomics igamije, gupima amatsinda asobanuwe ya chimique kandi ibinyabuzima bisobanuwe na metabolite.
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Ibimera / Inyamaswa De novo Urukurikirane rwa Genome
De novoGukurikirana bivuga kubaka ubwoko bwubwoko bwose ukoresheje tekinoroji ikurikirana, urugero nka PacBio, Nanopore, NGS, nibindi, iyo hatabayeho genome.Iterambere ritangaje mubisomwa byuburebure bwikurikiranya rya gatatu byazanye amahirwe mashya yo guteranya genome zigoye, nkizifite ubutumburuke bukabije, igipimo kinini cy’uturere dusubiramo, polyploide, nibindi hamwe nuburebure bwasomwe kurwego rwa kilobase icumi, ibi bisomwa bikurikirana birashoboka gukemura ibintu bisubiramo, uturere dufite ibintu bidasanzwe bya GC nibindi bice bigoye cyane.
Ihuriro ： PacBio Urukurikirane rwa II / Nanopore PromethION P48 / Illumina NovaSeq6000
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Muraho-C ishingiye ku Nteko rusange
Hi-C nuburyo bwateguwe bwo gufata chromosome iboneza muguhuza probe hafi yimikoranire ishingiye kumurongo hamwe no kwinjiza byinshi.Imbaraga ziyi mikoranire zizera ko zifitanye isano mbi nintera yumubiri kuri chromosomes.Kubwibyo, Hi-C amakuru ashobora kuyobora ihuriro, gutondekanya no kwerekana icyerekezo gikusanyirijwe mumushinga wa genome no guhuza ibyo kuri numero runaka ya chromosomes.Iri koranabuhanga riha imbaraga chromosome yo murwego rwa genome mugihe hatabayeho ikarita ishingiye kubaturage.Buri genome imwe ikenera Hi-C.
Ihuriro ： Illumina NovaSeq6000 / DNBSEQ
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Ubwihindurize
Imiterere y'ubwihindurize ni serivisi ikurikiranye igamije gutanga ibisobanuro birambuye ku makuru y'ubwihindurize y'ibikoresho byatanzwe bishingiye ku guhindagurika kw'ibinyabuzima, harimo SNPs, InDels, SVs na CNVs.Itanga isesengura ryibanze risabwa mugusobanura impinduka zubwihindurize nibiranga ubwoko bwabaturage, nkimiterere yabaturage, ubwoko butandukanye, imibanire ya phylogene, nibindi.
