I whakaratohia e BMKGENE nga ratonga raupapa RNA kore-waehere roa mo te tuhinga "Ko te nanoformula o te waikawa zoledronic me te konupūmā warowaihā e aro ana ki nga osteoclasts me te whakahuri i te osteoporosis", i whakaputaina i roto i te Biomaterials, i konei, ka whakawhanakehia he nanoplatform-HMCZP a OCs 'microenvironment-responsive nanoplatform-HMCZP.
Ko te rangahau e whakaatu ana he pai ake te HMCZP ki te aukati i nga mahi OC pakeke me te huri i te mate o nga wheua punaha i roto i nga kiore ovariectomized ka whakaritea ki te rongoa tuatahi.Ko te raupapatanga RNA teitei (RNA-seq) i whakaatu ka taea e te HMCZP te whakaheke i tetahi whaainga nui mo te osteoporosis, te waikawa waikawa phosphatase (TRAP), me etahi atu whaainga rongoa.Ko enei kitenga e kii ana ko te whakamahi i te nanoplatform mohio e aro ana ki nga OC he rautaki pai mo te rongoa osteoporosis.
Pāwhirikoneiki te ako atu mo tenei rangahau.
Wā tuku: Tihema-20-2023