I-BMKGENE ibonelele ngeenkonzo zokulandelelana kwe-transcriptomics yendawo kolu phononongo: i-Drosophila homologue enokubakho ye-mammalian adhesion GPCRs, ibandakanyeka kwiimpendulo ze-antitumor kwiiseli ze-oncogenic ezitofelweyo kwiimpukane, eyapapashwa kwi-PNAS, mthl1.
Kolu phononongo, iimpukane eziyindoda ezikhulileyo zatofwa ngee-OCs, kwaye ulandelelwano lwe-spatial transcriptome kwiimpukane ezikhenkcezisiweyo lwenziwa.Inaliti yee-OCs kwiimpukane eziyindoda endala ibangela impendulo eyomeleleyo kwi-transcriptomic kwinginginya yeempukane ezineekhowudi zofuzo ze-bona fide G-coupled proteins, phakathi kwazo i-gene ye-methusela-like 1 ibalasele.
Ngokudityaniswa kokuguqulwa kofuzo lwemfuza ye-mthl1 (ukulahleka komsebenzi kunye nokugqithiswa kwe-mthl1), kubhalwe ukuba ngokwenene lo mfuzo unempembelelo yokuchasa.Ngaphaya koko, bonisa ukuba i-mthl1 ilawula ukubonakaliswa kwenani elikhulu leekhowudi zofuzo ze-chemoreceptors kunye nofuzo olubandakanyekayo kulawulo lophuhliso.Ukucacisa iindlela zokuzikhusela zeempukane ngokuchasene namathumba ngokungabikho kokhuselo oluguqukayo.
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Ixesha lokuposa: Aug-10-2023