I-RNA yeSetyhula (i-circRNA) luhlobo lwe-RNA engeyiyo ikhowudi, efunyenwe kutshanje ukuba idlala indima ebalulekileyo kuthungelwano olulawulayo olubandakanyekayo ekuphuhliseni, ukuchasana nokusingqongileyo, njl njl. Ukwahluke kwiimolekyuli ze-RNA ezinomgca, umzekelo, i-mRNA, i-lncRNA, i-3 kunye ne-5 Iziphelo ze-circRNA zidityaniswe kunye zenza ulwakhiwo lwesetyhula, olubasindisa ekugayweni kwe-exonuclease kwaye bazinze ngakumbi kune-RNA eninzi.I-CircRNA ifunyenwe inemisebenzi eyahlukeneyo yokulawula ukubonakaliswa kofuzo.I-CircRNA inokusebenza njenge-ceRNA, ebopha i-miRNA ngokhuphiswano, eyaziwa ngokuba yi-miRNA sponge.Iqonga lokuhlalutya lokulandelelana kwe-CircRNA lixhobisa ubume be-circRNA kunye nohlalutyo lwentetho, ukuqikelela okujoliswe kuko kunye nohlalutyo oludibeneyo kunye nezinye iintlobo zeemolekyuli ze-RNA.
Bioinformatics
