Imikhiqizo

Ucwaningo lokuhlobana kwezakhi zofuzo (i-GWAS) luhlose ukuhlonza izinhlobo ezahlukene zezakhi zofuzo (i-genotype) ezihlotshaniswa nezici ezithile (i-phenotype). Izifundo ze-GWA zihlola izimpawu zezakhi zofuzo eziwela i-genome yonke yabantu abaningi futhi zibikezela ukuhlangana kwezakhi zofuzo-i-phenotype ngokuhlaziywa kwezibalo ezingeni labantu. Ukulandelana kabusha kwezakhi zofuzo kungathola cishe zonke izinhlobo zezakhi zofuzo. Uma kuhlanganiswa nedatha ye-phenotypic, i-GWAS ingacutshungulwa ukuze kuhlonzwe ama-SNP ahlobene ne-phenotype, ama-QTL kanye nezakhi zofuzo ezikhethiwe, okusekela kakhulu ukuzalaniswa kwezilwane/izitshalo kwesimanje. I-SLAF isu lokulandelelana kwezakhi zofuzo elenziwe lula, elithola izimpawu ezisakazwa nge-genome, i-SNP. Lawa ma-SNP, njengezimpawu zezakhi zofuzo zama-molecule, angacutshungulwa ukuze kuhlonzwe izici ezihlosiwe. Liyisu elingabizi kakhulu ekuboneni izici eziyinkimbinkimbi ezihambisana nokwehlukahluka kwezakhi zofuzo.