GENOME EVOLUTION, PANGENOME
He aha ka Pan-genome?
Hōʻike nā hōʻike i hōʻiliʻili ʻia he nui ka ʻokoʻa ma waena o nā ʻano ʻano like ʻole.ʻAʻole lawa kahi genome hoʻokahi no ka loaʻa ʻana o ke kiʻi holoʻokoʻa o ka ʻike genetic o kahi ʻano hoʻokahi.ʻO ke kumu o ke aʻo ʻana ʻo Pan-genome ka loaʻa ʻana o ka pakuhi genomic ʻoi aku ka piha o kahi ʻano a hoʻokaʻawale i nā pilina ma waena o nā ʻano a me nā code genetic ma o ke alakaʻi ʻana i ka hui genome de novo o nā ʻano ʻano he nui, kahi e hiki ai ke hoʻonui hohonu a ākea o nā ʻano like ʻole.
Nā ʻano o ka Pan-genome Study
Kiʻi 1 Nā ʻano o nā pepa noiʻi i paʻi ʻia o Pan-genome.
Nānā: Hōʻike ke kiʻi i ka hopena o ka lawe ʻana i ka "pan-genome" ma ke ʻano he huaʻōlelo nui e ʻimi ai i nā poʻo inoa o nā ʻatikala i paʻi ʻia ma nā puke moʻolelo Nature, Cell and Science.
a.Hoʻopili ʻia nā mea heluhelu mai nā laʻana he nui i kahi kuhikuhi a ʻākoakoa ʻia nā mea i hui ʻole ʻia i loko o nā contigs novel.Ma ka hoʻohui ʻana i kēia mau contigs moʻolelo i ke kaʻina kuhikuhi kumu, hiki ke kūkulu ʻia kahi kuhikuhi pangenome.Hoʻoholo ʻia nā ʻāpana ʻokoʻa ma muli o ka palapala ʻana i nā heluhelu a pau i ka pangenome.
b.ʻO ka hui de novo o nā genomes o nā komo ʻana he nui e ʻae i nā ala hoʻonohonoho genome holoʻokoʻa e ʻike i nā ʻāpana genomic dispensable.
c.Hiki ke kūkulu ʻia kahi pakuhi pan-genome mai nā hoʻopololei genome holoʻokoʻa a i ʻole ma ka hui kiʻi de novo, nāna e mālama pono i nā ʻike like ʻole o nā ʻāpana hiki ke hāʻawi ʻia ma ke ʻano he ala kū hoʻokahi ma o ka pakuhi.
Pehea e hana ai i kahi Pan-genome?
Kiʻi 2 Hoʻohālikelike i nā ala pan-genome1
a.Hoʻopili ʻia nā mea heluhelu mai nā laʻana he nui i kahi kuhikuhi a ʻākoakoa ʻia nā mea i hui ʻole ʻia i loko o nā contigs novel.Ma ka hoʻohui ʻana i kēia mau contigs moʻolelo i ke kaʻina kuhikuhi kumu, hiki ke kūkulu ʻia kahi kuhikuhi pangenome.Hoʻoholo ʻia nā ʻāpana ʻokoʻa ma muli o ka palapala ʻana i nā heluhelu a pau i ka pangenome.
b.ʻO ka hui de novo o nā genomes o nā komo ʻana he nui e ʻae i nā ala hoʻonohonoho genome holoʻokoʻa e ʻike i nā ʻāpana genomic dispensable.
c.Hiki ke kūkulu ʻia kahi pakuhi pan-genome mai nā hoʻopololei genome holoʻokoʻa a i ʻole ma ka hui kiʻi de novo, nāna e mālama pono i nā ʻike like ʻole o nā ʻāpana hiki ke hāʻawi ʻia ma ke ʻano he ala kū hoʻokahi ma o ka pakuhi.
Nā Pan-genomes i hoʻopuka hou ʻia
● Rape pan-genomes2
● Pan-genomes ʻo Tomato 3
● Laiki Pan -genome4
● Sunflower Pan-genome5
● Soybean Pan-genome 6
● Laiki Pan-genome7
● Barley Pan-genome8
● Wheat Pan-genome9
● Sorghum Pan-genome10
● Phytoplankton Pan-genome11
Kuhikuhi
1. ʻO Bayer PE, Golicz AA, Scheben A, Batley J, Edwards D. ʻO nā pan-genomes nā mea kanu ke kuhikuhi hou.Nā mea kanu Nat.2020;6(8):914-920.doi:10.1038/s41477-020-0733-0
2. Mele JM, Guan Z, Hu J, et al.ʻEwalu mau genome kiʻekiʻe e hōʻike ana i ka hoʻolālā pan-genome a me ka hoʻokaʻawale ʻana o ka ecotype o Brassica napus.Nā mea kanu Nat.2020;6(1):34-45.doi:10.1038/s41477-019-0577-7
3. Gao L, Gonda I, Sun H, et al.Hōʻike ka pan-genome i ka ʻōmato i nā genes hou a me kahi allele e hoʻoponopono ana i ka ʻono hua.Nat Genet.2019;51(6):1044-1051.doi:10.1038/s41588-019-0410-2
4. Zhao Q, Feng Q, Lu H, et al.Hōʻike ka loiloi pan-genome i ka nui o ka hoʻololi genomic i mahi ʻia a me ka laiki hihiu [hōʻike ʻia ka hoʻoponopono i paʻi ʻia ma Nat Genet.2018 ʻAukake;50(8):1196].Nat Genet.2018;50(2):278-284.doi:10.1038/s41588-018-0041-z
5. Hübner S, Bercovich N, Todesco M, et al.Hōʻike ka nānā ʻana o ka sunflower pan-genome i ka hoʻololi ʻana o ka hybridization i ka ʻike gene a me ka pale ʻana i nā maʻi.Nā mea kanu Nat.2019;5(1):54-62.doi:10.1038/s41477-018-0329-0
6. Liu Y, Du H, Li P, et al.ʻO Pan-Genome o nā Soybeans Wild a Mahiʻai.Kelepona.2020;182(1):162-176.e13.doi:10.1016/j.cell.2020.05.023
7. Qin P, Lu H, Du H, et al.Hōʻike ʻo Pan-genome analysis o 33 genetically diverse rice accessions i nā ʻano genomic huna [hoʻopuka pūnaewele ma mua o ka paʻi ʻana, 2021 Mei 25].Kelepona.2021;S0092-8674(21)00581-X.doi:10.1016/j.cell.2021.04.046
8. Jayakodi M, Padmarasu S, Haberer G, et al.Hōʻike ka barley pan-genome i ka hoʻoilina huna o ka hānau ʻana.ʻAno.2020;588(7837):284-289.doi:10.1038/s41586-020-2947-8
9. Walkowiak S, Gao L, Monat C, et al.Hōʻike nā genome palaoa lehulehu i ka hoʻololi honua i ka hoʻoulu ʻana o kēia wā.ʻAno.2020;588(7837):277-283.doi:10.1038/s41586-020-2961-x
10. Tao Y, Luo H, Xu J, et al.ʻO ka hoʻololi nui ʻana i loko o ka pan-genome o ka sorghum mahiʻai a me ka ʻāhiu [i paʻi ʻia ma ka pūnaewele ma mua o ka paʻi ʻana, 2021 Mei 20].Nā mea kanu Nat.2021;10.1038 / s41477-021-00925-x.doi:10.1038/s41477-021-00925-x
11. Fan X, Qiu H, Han W, et al.Hōʻike ka phytoplankton pangenome i ka hoʻoili gene prokaryotic ākea o nā hana like ʻole.Sci Adv.2020;6(18):eaba0111.Hoʻopuka ʻia 2020 ʻApelila 29. doi:10.1126/sciadv.aba0111
Ka manawa hoʻouna: Jan-04-2022