GENOME EVOLUTION, PANGENOME
Kedu ihe bụ Pan-genome?
Ihe akaebe gbakọtara na-egosi na ọdịiche dị n'etiti ụdị dị iche iche nke ụdị nwere ike ibu nnukwu.Otu mkpụrụ ndụ ihe nketa dị anya nke ukwuu iji nweta nkọwa zuru oke nke ozi mkpụrụ ndụ ihe nketa nke otu ụdị.Ebumnuche nke ọmụmụ Pan-genome bụ iji nweta eserese genomic zuru oke nke ụdị dị iche iche na ịkọwapụta mmekọrịta dị n'etiti àgwà na koodu mkpụrụ ndụ ihe nketa site na ịme mgbakọ genome de novo nke ọtụtụ ụdị, nke na-enye ohere dị omimi na nke sara mbara nke ọdịiche.
Usoro ọmụmụ Pan-genome
Ọgụgụ 1 Usoro nke akwụkwọ nyocha ebipụtara nke Pan-genome.
Rịba ama: Ọnụ ọgụgụ a na-egosi nsonaazụ nke iwere "pan-genome" dị ka isi okwu iji chọọ aha isiokwu ndị e bipụtara na akwụkwọ akụkọ Nature, Cell and Science.
a.A na-ahazi ihe ndị a na-agụ n'ọtụtụ nlele na ntụnye aka na ndị na-adaghị adaba na-agbakọta n'ime contigs ọhụrụ.Site n'ịgbakwunye akwụkwọ akụkọ ndị a n'usoro ntụaka izizi, enwere ike wuo ntụaka pangenome.A na-ekpebi mpaghara ndị a ga-achụpụ na-adabere na ịse eserese niile a na-agụghachi na pangenome.
b.Mgbakọ De novo nke genomes nke otutu accessions na-enye ohere usoro nhazi genome dum iji chọpụta mpaghara genomic dispensable.
c.Enwere ike ịmepụta eserese pan-genome site na nhazi genome dum ma ọ bụ site na mgbakọ de novo graph, nke na-echekwa ozi dị iche iche nke mpaghara a na-ekesa nke ọma dị ka ụzọ pụrụ iche site na eserese ahụ.
Kedu ka esi arụ Pan-genome?
Ọgụgụ 2 Ntụle nke pan-genome nso1
a.A na-ahazi ihe ndị a na-agụ n'ọtụtụ nlele na ntụnye aka na ndị na-adaghị adaba na-agbakọta n'ime contigs ọhụrụ.Site n'ịgbakwunye akwụkwọ akụkọ ndị a n'usoro ntụaka izizi, enwere ike wuo ntụaka pangenome.A na-ekpebi mpaghara ndị a ga-achụpụ na-adabere na ịse eserese niile a na-agụghachi na pangenome.
b.Mgbakọ De novo nke genomes nke otutu accessions na-enye ohere usoro nhazi genome dum iji chọpụta mpaghara genomic dispensable.
c.Enwere ike ịmepụta eserese pan-genome site na nhazi genome dum ma ọ bụ site na mgbakọ de novo graph, nke na-echekwa ozi dị iche iche nke mpaghara a na-ekesa nke ọma dị ka ụzọ pụrụ iche site na eserese ahụ.
Pan-genomes ebipụtara nso nso a
● Na-edina pan-genome n'ike2
● Tomato pan-genomes 3
● Rice Pan-genome4
● Sunflower Pan-genome5
● Soybean Pan-genome 6
● Rice Pan-genome7
● Barley Pan-genome8
● Ọka wit Pan-genome9
● Sorghum Pan-genome10
● Phytoplankton Pan-genome11
Ntụaka
1. Bayer PE, Golicz AA, Scheben A, Batley J, Edwards D. Plant pan-genomes bụ akwụkwọ ntụaka ọhụrụ.Osisi Nat.2020; 6 (8): 914-920 .doi:10.1038/s41477-020-0733-0
2. Abụ JM, Guan Z, Hu J, et al.Genomy dị elu asatọ na-ekpughe ihe owuwu pan-genome na ecotype dị iche iche nke Brassica napus.Osisi Nat.2020; 6 (1): 34-45 .doi:10.1038/s41477-019-0577-7
3. Gao L, Gonda I, Sun H, et al.Tomato pan-genome na-ekpughe mkpụrụ ndụ ihe nketa ọhụrụ yana ihe na-adịghị ahụkebe na-achịkwa ụtọ mkpụrụ osisi.Na Genet.2019;51 (6): 1044-1051 .doi: 10.1038/s41588-019-0410-2
4. Zhao Q, Feng Q, Lu H, et al.Nyocha pan-genome na-akọwapụta oke mgbanwe mkpụrụ ndụ ihe nketa na osikapa a kụrụ akụ na nke ọhịa [mmezi ebipụtara pụtara na Nat Genet.2018 Ọgọst; 50 (8): 1196 .Na Genet.2018;50 (2):278-284 .doi: 10.1038/s41588-018-0041-z
5. Hübner S, Bercovich N, Todesco M, et al.Nnyocha pan-genome nke sunflower na-egosi na ijikọ ọnụ gbanwere ọdịnaya mkpụrụ ndụ ihe nketa na nguzogide ọrịa.Osisi Nat.2019; 5 (1): 54-62 .doi:10.1038/s41477-018-0329-0
6. Liu Y, Du H, Li P, et al.Pan-Genome nke anụ ọhịa na soybe a kụrụ.Cell.2020;182(1):162-176.e13.doi:10.1016/j.cell.2020.05.023
7. Qin P, Lu H, Du H, et al.Nyocha pan-genome nke ụdị osikapa iri atọ na atọ dị iche iche na-ekpughe ụdịdị genomic zoro ezo [bipụtara n'ịntanetị tupu ebipụta, 2021 Mee 25].Cell.2021; S0092-8674 (21) 00581-X.doi:10.1016/j.cell.2021.04.046
8. Jayakodi M, Padmarasu S, Haberer G, et al.Pan-genome ọka bali na-ekpughe ihe nketa zoro ezo nke ịmụmụ mkpụrụ ndụ.Ọdịdị.2020;588(7837):284-289 .doi:10.1038/s41586-020-2947-8
9. Walkowiak S, Gao L, Monat C, et al.Ọtụtụ mkpụrụ ndụ ihe nketa ọka wit na-ekpughe mgbanwe zuru ụwa ọnụ na ozuzu ọgbara ọhụrụ.Ọdịdị.2020;588(7837):277-283 .doi: 10.1038/s41586-020-2961-x
10. Tao Y, Luo H, Xu J, et al.Ọdịiche dị ukwuu n'ime pan-genome nke sorghum a kụrụ na nke ọhịa [ebipụtara n'ịntanetị tupu ebipụta ya, Mee 2021].Osisi Nat.2021; 10.1038 / s41477-021-00925-x.doi: 10.1038/s41477-021-00925-x
11. Fan X, Qiu H, Han W, et al.Phytoplankton pangenome na-ekpughe nnukwu mkpụrụ ndụ prokaryotic kwụ ọtọ na-ebufe ọrụ dị iche iche.Sci Adv.2020; 6 (18): eaba0111.Ebipụtara 2020 Apr 29. doi:10.1126/sciadv.aba0111
Oge nzipu: Jan-04-2022