GENOME EVOLUTION, PANGENOME
Kodi Pan-genome ndi chiyani?
Umboni wochuluka umasonyeza kuti kusiyana pakati pa mitundu yosiyanasiyana ya zamoyo kungakhale kwakukulu.Mtundu umodzi wa genome ndi wosakwanira kupeza chithunzi chonse cha chibadwa cha mtundu umodzi.Cholinga cha kafukufuku wa Pan-genome ndikupeza chithunzi chokwanira cha mitundu ya zamoyo ndikuzindikira maubwenzi omwe ali pakati pa makhalidwe ndi ma genetic code poyendetsa mitundu yosiyanasiyana ya ma genome de novo, zomwe zimalola kukumba mozama komanso mokulirapo kwa mitunduyo.
Makhalidwe a Pan-genome Study
Chithunzi 1 Zomwe zimachitika pamapepala ofufuza ofalitsidwa a Pan-genome.
Chidziwitso: Chiwerengerochi chikuwonetsa zotsatira zotengera "pan-genome" ngati liwu lofunikira pakufufuza mitu yankhani zofalitsidwa m'magazini a Nature, Cell and Science.
a.Zowerengedwa kuchokera ku zitsanzo zingapo zimagwirizanitsidwa ndi zomwe zimatchulidwa ndipo zosasinthika zimasonkhanitsidwa kukhala ma contigs atsopano.Powonjezera ma contig awa pamayendedwe oyambira, mafotokozedwe a pangenome atha kupangidwa.Madera omwe angagwiritsidwe ntchito amatsimikiziridwa kutengera mapu omwe amawerengedwanso ku pangenome.
b.Msonkhano wa De novo wa ma genomes of multiple accessions amalola njira zonse zolumikizirana ndi ma genome kuti zizindikire zigawo zomwe zimatha kupezeka.
c.Pan-genome graph imatha kupangidwa kuchokera ku ma genome onse kapena ndi de novo graph assembly, yomwe imasunga bwino zidziwitso zosiyanasiyana za zigawo zomwe zingagwiritsidwe ntchito ngati njira zapadera kudzera pa graph.
Momwe mungapangire Pan-genome?
Chithunzi 2 Kuyerekeza kwa njira za pan-genome1
a.Zowerengedwa kuchokera ku zitsanzo zingapo zimagwirizanitsidwa ndi zomwe zimatchulidwa ndipo zosasinthika zimasonkhanitsidwa kukhala ma contigs atsopano.Powonjezera ma contig awa pamayendedwe oyambira, mafotokozedwe a pangenome atha kupangidwa.Madera omwe angagwiritsidwe ntchito amatsimikiziridwa kutengera mapu omwe amawerengedwanso ku pangenome.
b.Msonkhano wa De novo wa ma genomes of multiple accessions amalola njira zonse zolumikizirana ndi ma genome kuti zizindikire zigawo zomwe zimatha kupezeka.
c.Pan-genome graph imatha kupangidwa kuchokera ku ma genome onse kapena ndi de novo graph assembly, yomwe imasunga bwino zidziwitso zosiyanasiyana za zigawo zomwe zingagwiritsidwe ntchito ngati njira zapadera kudzera pa graph.
Posachedwapa Pan-genomes
● Kugwiririra pan-genomes2
● Tomato pan-genomes 3
● Mpunga Pan -genome4
● Mpendadzuwa Pan-genome5
● Soya Pan-genome 6
● Mpunga Pan-genome7
● Barley Pan-genome8
● Tirigu Pan-genome9
● Manyowa a Pan-genome10
● Phytoplankton Pan-genome11
Buku
1. Bayer PE, Golicz AA, Scheben A, Batley J, Edwards D. Plant pan-genomes ndizofotokozera zatsopano.Nat Plants.2020; 6(8):914-920.doi:10.1038/s41477-020-0733-0
2. Nyimbo JM, Guan Z, Hu J, et al.Ma genome asanu ndi atatu apamwamba kwambiri amawulula kamangidwe ka pan-genome komanso kusiyanitsa kwachilengedwe kwa Brassica napus.Nat Plants.2020; 6(1):34-45.doi:10.1038/s41477-019-0577-7
3. Gao L, Gonda I, Sun H, et al.Tomato pan-genome amavumbulutsa majini atsopano komanso kakomedwe kosowa ka zipatso.Nat Genet.2019;51(6):1044-1051.doi:10.1038/s41588-019-0410-2
4. Zhao Q, Feng Q, Lu H, et al.Kusanthula kwa Pan-genome kumawonetsa kuchuluka kwa kusiyana kwa ma genomic mu mpunga wolimidwa komanso wamtchire [kukonza kosindikizidwa kumapezeka mu Nat Genet.2018 Aug; 50 (8): 1196].Nat Genet.2018;50(2):278-284.doi:10.1038/s41588-018-0041-z
5. Hübner S, Bercovich N, Todesco M, et al.Kusanthula kwa mpendadzuwa pan-genome kukuwonetsa kuti kusakanizidwa kunasintha ma jini komanso kukana matenda.Nat Plants.2019;5(1):54-62.doi:10.1038/s41477-018-0329-0
6. Liu Y, Du H, Li P, et al.Pan-Genome ya Soya Wakuthengo ndi Wolima.Selo.2020;182(1):162-176.e13.doi:10.1016/j.cell.2020.05.023
7. Qin P, Lu H, Du H, et al.Kusanthula kwa Pan-genome kwa 33 mitundu yosiyanasiyana ya mpunga kumasonyeza kusiyana kobisika kwa ma genomic [kusindikizidwa pa intaneti tisanasindikizidwe, 2021 May 25].Selo.2021;S0092-8674(21)00581-X.doi:10.1016/j.cell.2021.04.046
8. Jayakodi M, Padmarasu S, Haberer G, et al.Barley pan-genome amawulula cholowa chobisika cha kuswana kwa masinthidwe.Chilengedwe.2020;588(7837):284-289.doi:10.1038/s41586-020-2947-8
9. Walkowiak S, Gao L, Monat C, et al.Ma genome ambiri a tirigu amawonetsa kusiyanasiyana kwapadziko lonse pakuswana kwamakono.Chilengedwe.2020;588(7837):277-283.doi:10.1038/s41586-020-2961-x
10. Tao Y, Luo H, Xu J, et al.Kusiyanasiyana kwakukulu mkati mwa pan-genome ya manyuchi amtchire [osindikizidwa pa intaneti asanasindikizidwe, 2021 May 20].Nat Plants.2021;10.1038 / s41477-021-00925-x.doi:10.1038/s41477-021-00925-x
11. Fan X, Qiu H, Han W, et al.Phytoplankton pangenome ikuwonetsa kusamutsa kwamitundu yopingasa ya prokaryotic yamitundu yosiyanasiyana.Sci Adv.2020; 6(18):aba0111.Lofalitsidwa 2020 Apr 29. doi:10.1126/sciadv.aba0111
Nthawi yotumiza: Jan-04-2022