Juyin Halitta, PANGENOME
Menene Pan-genome?
Shaidun da aka tara nuna cewa bambanci tsakanin sashin halittu daban-daban na iya zama mai girma.Kwayoyin halitta guda ɗaya ya yi nisa don samun cikakken hoto na bayanan kwayoyin halitta guda ɗaya.Dalilin binciken PAN-GASKIYA shine samun cikakkiyar jadawalin zane-zane na jinsi da kuma daidaita alakar da ke tsakanin Noovo ta hanyar ɗaukar ɗimbin yawa na bambance-bambancen.
Hanyoyin Nazarin Pan-genome
Hoto 1 Hanyoyin da aka buga na takardun bincike na Pan-genome.
Lura: Adadin yana nuna sakamakon ɗaukar "pan-genome" azaman maɓalli don bincika taken labaran da aka buga a cikin jerin mujallolin Nature, Cell da Kimiyya
a.An jera karatu daga samfurori da yawa zuwa ga tunani kuma waɗanda ba a haɗa su ba an haɗa su cikin sabbin abubuwa.Ta ƙara waɗannan ƙa'idodin sabon labari zuwa jeri na asali, ana iya gina ma'anar pangenome.An ƙaddara yankuna da za a iya raba su bisa taswira duk an karanta su zuwa ga pangenome.
b.De novo taro na genomes na mahara accessions damar dukan genome hanyoyin jeri don gano dispensable genomic yankuna.
c.Za a iya gina ginshiƙi na pan-genome daga gabaɗayan jeri na genome ko ta hanyar taron jadawali, wanda ke adana bambance-bambancen bayanai na yankuna da za a iya raba su da kyau azaman hanyoyi na musamman ta cikin jadawali.
Yadda za a gina Pan-genome?
Hoto 2 Kwatanta hanyoyin pan-genome1
a.An jera karatu daga samfurori da yawa zuwa ga tunani kuma waɗanda ba a haɗa su ba an haɗa su cikin sabbin abubuwa.Ta ƙara waɗannan ƙa'idodin sabon labari zuwa jeri na asali, ana iya gina ma'anar pangenome.An ƙaddara yankuna da za a iya raba su bisa taswira duk an karanta su zuwa ga pangenome.
b.De novo taro na genomes na mahara accessions damar dukan genome hanyoyin jeri don gano dispensable genomic yankuna.
c.Za a iya gina ginshiƙi na pan-genome daga gabaɗayan jeri na genome ko ta hanyar taron jadawali, wanda ke adana bambance-bambancen bayanai na yankuna da za a iya raba su da kyau azaman hanyoyi na musamman ta cikin jadawali.
Pan-genomes da aka buga kwanan nan
● Fyade pan-genomes2
● Tumatir pan-genomes 3
● Shinkafa Pan-genome4
● Sunflower Pan-genome5
● Waken soya Pan-genome 6
● Shinkafa Pan-genome7
● Sha'ir Pan-genome8
● Alkama Pan-genome9
● Sorghum Pan-genome10
● Phytoplankton Pan-genome11
Magana
1. Bayer PE, Golicz AA, Scheben A, Batley J, Edwards D. Plant pan-genomes ne sabon tunani.Tsire-tsire Nat.2020; 6 (8): 914-920.doi:10.1038/s41477-020-0733-0
2. Song JM, Guan Z, Hu J, et al.Kwayoyin halitta takwas masu inganci sun bayyana gine-ginen pan-genome da bambance-bambancen ecotype na Brassica napus.Tsire-tsire Nat.2020; 6 (1): 34-45.doi:10.1038/s41477-019-0577-7
3. Gao L, Gonda I, Sun H, et al.Tumatir pan-genome yana buɗe sabbin kwayoyin halitta da ƙarancin allele mai sarrafa ɗanɗanon 'ya'yan itace.Ina Genet.2019;51 (6): 1044-1051.doi:10.1038/s41588-019-0410-2
4. Zhao Q, Feng Q, Lu H, et al.Binciken pan-genome yana nuna girman bambancin genomic a cikin noma da shinkafar daji [gyara da aka buga ya bayyana a cikin Nat Genet.2018 Agusta;50 (8):1196].Ina Genet.2018;50 (2):278-284.doi:10.1038/s41588-018-0041-z
5. Hübner S, Bercovich N, Todesco M, et al.Binciken pan-genome na sunflower ya nuna cewa haɓakawa ya canza abun cikin kwayoyin halitta da juriya na cututtuka.Tsire-tsire Nat.2019; 5 (1): 54-62.doi:10.1038/s41477-018-0329-0
6. Liu Y, Du H, Li P, et al.Pan-Genome na Daji da Noma waken soya.Cell.2020; 182 (1): 162-176.e13.doi:10.1016/j.cell.2020.05.023
7. Qin P, Lu H, Du H, et al.Binciken pan-genome na nau'ikan shinkafa iri-iri iri-iri 33 yana bayyana ɓoyayyun bambance-bambancen kwayoyin halitta [wanda aka buga akan layi kafin bugawa, 2021 Mayu 25].Cell.2021; S0092-8674(21)00581-X.doi:10.1016/j.cell.2021.04.046
8. Jayakodi M, Padmarasu S, Haberer G, et al.Ganyen-genome na sha'ir yana bayyana ɓoyayyun gadon halittar maye gurbi.Yanayi.2020;588(7837):284-289.doi:10.1038/s41586-020-2947-8
9. Walkowiak S, Gao L, Monat C, et al.Kwayoyin halittar alkama da yawa sun bayyana bambancin duniya a kiwo na zamani.Yanayi.2020;588 (7837):277-283.doi:10.1038/s41586-020-2961-x
10. Tao Y, Luo H, Xu J, et al.Bambance-bambance mai yawa a cikin nau'in nau'in nau'in nau'in nau'in nau'in dawa da aka noma da daji [wanda aka buga akan layi kafin bugawa, 2021 Mayu 20].Tsire-tsire Nat.2021; 10.1038 / s41477-021-00925-x.doi:10.1038/s41477-021-00925-x
11. Fan X, Qiu H, Han W, et al.Phytoplankton pangenome yana bayyana fa'idar prokaryotic a kwance hanyar canja wurin ayyuka daban-daban.Sci Adv.2020; 6 (18): eaba0111.An buga 2020 Apr 29. doi:10.1126/sciadv.aba0111
Lokacin aikawa: Janairu-04-2022