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Prokaryotic RNA sequencing
Prokaryotic RNA sequencing uses next generation sequencing (NGS) to reveal the presence and quantity of RNA at a given moment, by analyzing the changing cellular transcriptome. Our company‘s prokaryotic RNA sequencing, specifically aims at prokaryotes with reference genomes, providing you with transcriptome profiling, gene structure analysis, etc. It has been widely applied to basic science research, drug research and development, and more.
Platform: Illumina NovaSeq Platform
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Metatranscriptome Sequencing
Metatranscriptome sequencing indentifies gene expression of microbes (both eukaryotes and prokaryotes) within natural enviroments (i.e. soil, water, sea, feces, and gut.).Specifically, this services allows you to obtain whole gene expression profiling of complex microbial communities, taxonomic analysis of species, functional enrichment analysis of differently expressed genes, and more.
Platform: Illumina NovaSeq Platform
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Fungal Genome
Biomarker Technologies provide genome survey, fine genome and pene-complete genome of fungal depending on specific research goal. Genome sequencing, assembly and functional annotation can be achieved by combining Next-generation sequencing + Third generation sequencing to achieve high-level genome assembly. Hi-C technology can also be employed to facilitate genome assembly at chromosome level.
Platform：PacBio Sequel II
Nanopore PromethION P48
Illumina NovaSeq Platform
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Toolkits
BMKCloud is a leading bioinformatic platform providing one-stop solution for genomic programs, which is widely trusted by researchers in various arena including medical, agricultural, environmental, etc. BMKCloud is committed to provide integrated, reliable and efficient services including bioinformatic analysis platforms and tools, computing resources, public database, bioinformtic online courses, etc. BMKCloud has various frequently used bioinformatic tools of including gene annotation, evolutionary genetic tools, ncRNA, data quality control, assembly, alignment, data extraction, mutations, statistics, figure generator, sequence analysis,etc.
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Bacteria Complete Genome
Biomarker Technologies provides sequencing service on constructing complete genome of bacteria with zero gap. Main workflow of bacteria complete genome construction includes third generation sequencing, assembly, functional annotation and advanced bioinformatic analysis fulfilling specific research goals. A more comprehensive profiling of bacteria genome empowers revealing of fundamental mechanisms underlying their biological processes, which could also provide valuable reference for genomic researches in higher eukaryotic species
Platform：Nanopore PromethION P48 + Illumina NovaSeq Platform
PacBio Sequel II
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small RNA
Small RNAs are type of short non-coding RNA with average length of 18-30 nt, including miRNA, siRNA and piRNA. These small RNAs have been massively reported to be involved in various biological processes such as mRNA degradation, translation inhibition, heterochromatin formation, etc. SmallRNA sequencing analysis has been widely applied in studies on animal/plant development, disease, virus, etc. Small RNA sequencing analysis platform consists of standard analysis and advanced data mining. On base of RNA-seq data, standard analysis can achieve miRNA identification and prediction, miRNA target gene prediction, annotation and expression analysis. Advanced analysis enables customized miRNA search and extraction, Venn diagram generation, miRNA and target gene network building.
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NGS-WGS (Illumina/BGI)
NGS-WGS is an whole genome re-sequencing analysis platform, which is developed on base of rich experience in Biomarker Technologies. This ease-to-use platform allows quick submission of an integrated analysis workflow by simply setting a few basic parameter, which fits for DNA sequencing data generated from both Illumina platform and BGI sequencing platform. This platform is deployed on high performance computing server, which empowers highly efficient data analysis in very limited time. Personalized data mining is available on base of standard analysis, including mutated gene query, PCR primer design, etc.
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mRNA(Reference)
Transcriptome is the link between genomic genetic information and the proteome of biological function. Transcriptional level regulation is the most important and the most widely studied regulation mode of organisms. Transcriptome sequencing can sequence the transcriptome at any point in time or under any condition, with a resolution accurate to a single nucleotide.It can dynamically reflect the level of gene transcription, simultaneously identify and quantify rare and normal transcripts, and provide the structural information of sample specific transcripts.
At present, transcriptome sequencing technology has been widely used in agronomy, medicine and other research fields, including animal and plant development regulation, environmental adaptation, immune interaction, gene localization, species genetic evolution and tumor and genetic disease detection.
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Metagenomics (NGS)
This analysis platform is designed for shotgun metagenomic data analysis on base of years of experience. It consists integrated workflow containing various of commonly needed metagenomics analyses including data processing, species-level studies, gene function-level studies, metagenome binning, etc. In addition, customized data mining tools are available upon standard analysis workflow, including gene and species query, parameter setting, personalized figure generating, etc.
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LncRNA
Long non-coding RNAs (lncRNA) are a type of transcripts with length longer than 200 nt, which are unable to code proteins. Accumulative evidence suggests that most of lncRNAs are very likely to be functional. High-throughput sequencing technologies and bioinformatic analyzing tools empower us to reveal lncRNA sequences and positioning information more efficiently and lead us to discover lncRNAs with crucial regulatory functions. BMKCloud is proud to provide our customers lncRNA sequencing analysis platform to achieve fast, reliable and flexible lncRNA analysis.
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GWAS
Genome-wide association study (GWAS) aims at identifying genetic variants (genotype) that associated with specific traits (phenotype). GWA studies investigates genetic markers cross whole genome of large number of individuals and predicts genotype-phenotype associations by statistical analysis at population level. Whole-genome resequencing can potentially discover all genetic variants. Coupling with phenotypic data, GWAS can be processed to identify phenotype related SNPs, QTLs and candidate genes, which strongly backs up modern animal/plant breeding. SLAF is a self-developed simplified genome sequencing strategy, which discovers genome-wide distributed markers, SNP. These SNPs, as molecular genetic markers, can be processed for association studies with targeted traits. It is a cost-effective strategy in identifying complex traits associated genetic variations.
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Nanopore Full-length transcriptomics
Complex and variable alternative isoforms in organisms are important genetic mechanisms for regulating gene expression and protein diversity. Accurate identification of transcript structures is the basis for in-depth study of gene expression regulation patterns. Nanopore sequencing platform has successfully brought transcriptomic study to isoform-level. This analysis platform is designed to analyze RNA-Seq data generated on Nanopore platform on base of reference genome, which achieves qualitative and quantitative analyses in both gene level and transcripts level.
