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Bacterial And Fungal Whole Genome Re-Sequencing
Bacterial and fungal whole genome re-sequencing is a critical tool to complete the genomes of known bacterium and fungi, as well as to compare multiple genomes or to map genomes of new organisms. It is of great importance to sequence entire genomes of bacterium and fungi in order to generate accurate reference genomes, to do microbial identification and other comparative genome studies.
Platform:Illumina NovaSeq 6000
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PacBio-Full-length 16S/18S/ITS Amplicon Sequencing
Amplicon (16S/18S/ITS) platform is developed with years of experience in microbial diversity project analysis, which contains standardized basic analysis and personalized analysis: basic analysis covers the mainstream analysis content of current microbial research, the analysis content is rich and comprehensive, and analysis results are presented in the form of project reports; The content of personalized analysis is diverse. Samples can be selected and parameters can be set flexibly according to the basic analysis report and research purpose, to realize personalized requirements. Windows operating system, simple and fast.
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PacBio-Full-length Transcriptome (Non-Reference)
Taking Pacific Biosciences (PacBio) Isoform sequencing data as input, this App is able to identify full-length transcript sequences (without assembly). By mapping full-length sequences against reference genome, transcripts can be optimized by known genes, transcripts, coding regions, etc. In this case, more accurate identification of mRNA structures, such as alternative splicing, etc, can be achieved. Joint analysis with NGS transcriptome sequencing data enables more comprehensive annotation and more accurate quantification in expression at transcript level, which largely benefits downstream differential expression and functional analysis.
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Reduced Representation Bisulfite Sequencing (RRBS)
DNA methylation research has always been a hot topic in disease research, and is closely related to gene expression and pheno-typic traits. RRBS is an accurate, efficient and economical method for DNA methylation research. Enrichment of promoter and CpG island regions by enzymatic cleavage (Msp I), combined with Bisulfite sequencing, provides high resolution DNA methylation detection.
Platform: Illumina NovaSeq 6000
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Prokaryotic RNA sequencing
Prokaryotic RNA sequencing uses next generation sequencing (NGS) to reveal the presence and quantity of RNA at a given moment, by analyzing the changing cellular transcriptome. Our company‘s prokaryotic RNA sequencing, specifically aims at prokaryotes with reference genomes, providing you with transcriptome profiling, gene structure analysis, etc. It has been widely applied to basic science research, drug research and development, and more.
Platform: Illumina NovaSeq 6000
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Metatranscriptome Sequencing
Metatranscriptome sequencing indentifies gene expression of microbes (both eukaryotes and prokaryotes) within natural enviroments (i.e. soil, water, sea, feces, and gut.).Specifically, this services allows you to obtain whole gene expression profiling of complex microbial communities, taxonomic analysis of species, functional enrichment analysis of differently expressed genes, and more.
Platform: Illumina NovaSeq 6000
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Fungal Genome
Biomarker Technologies provide genome survey, fine genome and pene-complete genome of fungal depending on specific research goal. Genome sequencing, assembly and functional annotation can be achieved by combining Next-generation sequencing + Third generation sequencing to achieve high-level genome assembly. Hi-C technology can also be employed to facilitate genome assembly at chromosome level.
Platform：PacBio Sequel II
Nanopore PromethION P48
Illumina NovaSeq 6000
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Toolkits
BMKCloud is a leading bioinformatic platform providing one-stop solution for genomic programs, which is widely trusted by researchers in various arena including medical, agricultural, environmental, etc. BMKCloud is committed to provide integrated, reliable and efficient services including bioinformatic analysis platforms and tools, computing resources, public database, bioinformtic online courses, etc. BMKCloud has various frequently used bioinformatic tools of including gene annotation, evolutionary genetic tools, ncRNA, data quality control, assembly, alignment, data extraction, mutations, statistics, figure generator, sequence analysis,etc.
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Bacteria Complete Genome
Biomarker Technologies provides sequencing service on constructing complete genome of bacteria with zero gap. Main workflow of bacteria complete genome construction includes third generation sequencing, assembly, functional annotation and advanced bioinformatic analysis fulfilling specific research goals. A more comprehensive profiling of bacteria genome empowers revealing of fundamental mechanisms underlying their biological processes, which could also provide valuable reference for genomic researches in higher eukaryotic species
Platform：Nanopore PromethION P48 + Illumina NovaSeq 6000
PacBio Sequel II
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small RNA
Small RNAs are type of short non-coding RNA with average length of 18-30 nt, including miRNA, siRNA and piRNA. These small RNAs have been massively reported to be involved in various biological processes such as mRNA degradation, translation inhibition, heterochromatin formation, etc. SmallRNA sequencing analysis has been widely applied in studies on animal/plant development, disease, virus, etc. Small RNA sequencing analysis platform consists of standard analysis and advanced data mining. On base of RNA-seq data, standard analysis can achieve miRNA identification and prediction, miRNA target gene prediction, annotation and expression analysis. Advanced analysis enables customized miRNA search and extraction, Venn diagram generation, miRNA and target gene network building.
