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Single- nucleus RNA Sequencing
The advance in single cell capturing and individual library construction technique combining with high-throughput sequencing allows gene expression studies on cell-by-cell basis. It enables a deeper and complete system analysis on complex cell populations, in which it largely avoids masking of their heterogeneity by taking average of all cells.
However, some cells are not suitable to be made into single-cell suspension, so other sample preparation methods – nucleus extraction from tissues are needed, that is, nucleus is directly extracted from tissues or cell and prepared into single-nucleus suspension for single-cell sequencing.
BMK provides 10× Genomics ChromiumTM based single-cell RNA sequencing service. This service has been widely used in studies on disease related studies, such as immune cell differentiation, tumor heterogeneity, tissue development, etc.
Spatial transcriptome chip: 10× Genomics
Platform: Illumina NovaSeq Platform
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BMKMANU S1000 Spatial Transcriptome
Spatial organization of cells plays vital role in various biological processes, such as immune infiltration, embryo development, etc. Spatial transcriptome sequencing, which indicates gene expression profiling while retaining information of spatial position, has provide great insights into transcriptome-level tissue architecture. With the development of technology, the ultra-clear tissue morphology and the real structural difference of spatial molecular expression need to be studied with higher resolution. BMKGENE provides comprehensive, one-stop spatial transcriptome sequencing service from samples to biological insights.
Spatial transcriptomics technologies empowered novel perspectives in diverse research arena by resolving gene expression profile with spatial content in heterogenous samples.
Spatial transcriptome chip: BMKMANU S1000
Platform: Illumina NovaSeq Platform
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10x Genomics Visium Spatial Transcriptome
Visium Spatial Gene Expression is a mainstream spatial transcriptome sequencing technology for classifying tissue based on total mRNA. Map the whole transcriptome with morphological context to discover novel insights into normal development, disease pathology, and clinical translational research. BMKGENE provides comprehensive, one-stop spatial transcriptome sequencing service from samples to biological insights.
Spatial transcriptomics technologies empowered novel perspectives in diverse research arena by resolving gene expression profile with spatial content in heterogenous samples.
Spatial transcriptome chip: 10x Genomics Visium
Platform: Illumina NovaSeq Platform
