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Taxanaha Genome

  • Falanqaynta Ururka Genom-ballaaran

    Falanqaynta Ururka Genom-ballaaran

    Daraasada ururka genome-wide (GWAS) waxay ujeedadeedu tahay in lagu aqoonsado kala duwanaanshaha hidde-sideyaasha (genotype) ee la xidhiidha sifooyin gaar ah (phenotype).Daraasada GWAS waxay baartaa calaamadaha hidde-sidaha oo ka gudba genome-ga tiro badan oo shakhsiyaad ah waxayna saadaalisaa ururada genotype-phenotype iyadoo la adeegsanayo falanqaynta tirakoobka ee heerka dadweynaha.Waxaa si weyn loogu dabaqay cilmi-baaris ku saabsan cudurrada bini'aadamka iyo macdanta hidda-socodka ee shaqeynaya ee sifooyinka adag ee xayawaanka ama dhirta.

  • Isku-xiridda Hiddo-sidaha Dhan ee Dhirta/Xayawaanka

    Isku-xiridda Hiddo-sidaha Dhan ee Dhirta/Xayawaanka

    Dib-u-soo-celinta genome-ga oo dhan, oo sidoo kale loo yaqaan WGS, waxay awood u siinaysaa muujinta isku-beddellada caadiga ah iyo kuwa naadirka ah ee dhammaan genome-ga oo ay ku jiraan Single Nucleotide Polymorphism (SNP), Tirtirka Gelinta (InDel), Kala duwanaanshaha qaab-dhismeedka (SV), iyo Kala duwanaanshaha Tirada Nuqulka (CNV) ).SV-yadu waxay ka kooban yihiin qayb weyn oo ka mid ah saldhigga kala duwanaanshiyaha marka loo eego SNPs waxayna saameyn weyn ku leeyihiin genome-ka, taas oo saameyn weyn ku leh noolaha.Dib u akhrinta dheer waxay u ogolaanaysaa in si sax ah loo aqoonsado jajabyo waaweyn iyo kala duwanaansho adag sababtoo ah akhrinta dheer waxay aad u fududaynaysaa ka gudubka koromosoomyada ee gobolada adag sida soo noqnoqoshada tandem, GC/AT-gobolada qani ku ah, iyo gobolada isbedbeddelka badan.

    Platform: Illumina, PacBio, Nanopore

  • Hiddaha Kobcinta

    Hiddaha Kobcinta

    Hidde-raaca korriinka waa adeeg isku xigxig ah oo bakooban oo loogu talagalay in lagu bixiyo tafsiir dhammaystiran oo ku saabsan macluumaadka kobcinta agabka la bixiyay ee ku salaysan kala duwanaanshaha hidde-sideyaasha, oo ay ku jiraan SNPs, InDels, SVs iyo CNVs.Waxay bixisaa dhammaan falanqaynta aasaasiga ah ee loo baahan yahay si loo qeexo isbeddellada kobcinta iyo astaamaha hidda-wadaha ee dadyowga, sida qaab-dhismeedka dadweynaha, kala duwanaanshaha hidde-sidaha, xiriirka phylogeny, iwm. Waxa kale oo ay ka kooban tahay daraasado ku saabsan socodka hidda-wadaha, taas oo awood u siinaysa qiyaasta cabbirka dadweynaha ee waxtarka leh, waqtiga kala duwanaanshaha.

  • Isbarbardhigga Genomics

    Isbarbardhigga Genomics

    Genomics isbarbardhigga macno ahaan macnaheedu waa isbarbardhigga taxanaha genome-ga oo dhammaystiran iyo qaababka noocyada kala duwan.Anshaxaani waxay ujeedadeedu tahay muujinta horumarka noocyada, shaqada hidda-wadaha, habka nidaaminta hidda-wadaha ee heerka genome iyada oo la aqoonsanayo qaababka isku xigxiga iyo walxaha la dhawray ama lagu kala soocay noocyada kala duwan.Daraasada genomics isbarbardhigga caadiga ah waxaa ka mid ah falanqaynta qoyska hiddaha, horumarka korriinka, nuqulka hiddo-wadaha oo dhan, cadaadiska xulashada, iwm.

  • Golaha Genome ee saldhigiisu yahay Hi-C

    Golaha Genome ee saldhigiisu yahay Hi-C

    Hi-C waa hab loogu talagalay in lagu qabto qaabeynta koromosoomyada iyadoo la isku darayo isdhexgalka ku saleysan dhowaanshaha iyo isku xigxiga-sare.Xoogga is dhexgalkaan ayaa la rumeysan yahay inay si xun ula xiriirto fogaanta jireed ee koromosoomyada.Sidaa darteed, xogta Hi-C waxay hagi kartaa ururinta, dalbashada iyo jihaynta taxanaha la isku keenay ee hiddo-wadaha qabyada ah iyo ku xidhidhiyeyaasha tiro cayiman oo koromosoomyo ah.Farsamadani waxay awood siinaysaa isu imaatinka heerka koromosoomyada iyadoo ay maqan tahay khariidad hidde-wadaaga ku salaysan.Genom kasta wuxuu u baahan yahay Hi-C.

    Platform: Illumina NovaSeq Platform / DNBSEQ

  • Dhirta/Xayawaanka De Novo Genome Sequencing

    Dhirta/Xayawaanka De Novo Genome Sequencing

    De Novoisku xigxiga waxaa loola jeedaa dhisidda genome-ga nuucyada oo dhan iyadoo la adeegsanayo tignoolajiyada isku xigxiga, tusaale ahaan PacBio, Nanopore, NGS, iwm., iyadoo maqnaanshaha genome tixraaceed.Horumarka cajiibka ah ee dhererka akhriska ee tignoolajiyada isku xigxiga jiilka saddexaad ayaa keenay fursado cusub oo lagu ururiyo genome-ka adag, sida kuwa leh heterozygosity sare, saamiga sare ee gobollada soo noqnoqda, polyploids, iwm. xallinta canaasiirta soo noqnoqda, gobollo ka kooban GC aan caadi ahayn iyo gobollo kale oo aad u adag.

    Platform: PacBio Sequel II /Nanopore PromethION P48/ Illumina NovaSeq Platform

  • Isku xigxiga guud ee bini'aadamka

    Isku xigxiga guud ee bini'aadamka

    Taxanaha guud ee exome (WES) waxa loo tixgaliyaa istaraatijiyad isku xigxiga oo wax ku ool ah oo lagu garto isbedelada cudurada keena.Inkasta oo exons ay qaataan kaliya 1.7% dhammaan genome-ga, waxay u taagan tahay astaanta guud ee borotiinka si toos ah.In genome-ga bini'aadamka, ayaa la sheegay in in ka badan 85% isbeddellada la xiriira cudurrada ay ku dhacaan gobolka codeing borotiinka.

    BMKGENE waxay bixisaa adeegyo isku xigxiga oo dhan oo dabacsanaan leh oo bini aadamka ah oo leh xeelado kala duwan oo soo jiidasho leh oo la heli karo si loo gaaro yoolalka cilmi baarista ee kala duwan.

    Platform: Illumina NovaSeq Platform

  • Taxanaha Jajabka La Weyneeyay ee Gaarka ah-Locus (SLAF-Seq)

    Taxanaha Jajabka La Weyneeyay ee Gaarka ah-Locus (SLAF-Seq)

    Genotyping-sare-sare, gaar ahaan dadka tirada badan, waa tallaabo aasaasiga ah ee daraasadaha ururka hidde, kaas oo bixiya aasaaska hidde-helidda hiddo-wadaha functional, falanqaynta evolutionary, iwm. ) waxaa loo soo bandhigay si loo yareeyo qiimaha isku xigxiga ee muunad kasta, iyadoo la ilaalinayo waxtarka macquulka ah ee helitaanka calaamadeeyaha hidde-sideyaasha.Tan waxaa badanaa lagu gaaraa in la soo saaro jajab xaddidan oo ku dhex jira cabbirka cabbirka, kaas oo lagu magacaabo maktabad matalaad la dhimay (RRL).Taxanaha goos gooska gaarka ah ee goobta la kordhiyey (SLAF-Seq) waa istaraatiijiyad iskeed u horumarisay oo loogu talagalay SNP genotyping oo leh ama aan lahayn genome tixraaceed.
    Platform: Illumina NovaSeq Platform

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